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Application of jolkinolide B in preparation of drugs for preventing and treating chronic kidney diseases

A technology for petrosalactone and chronic kidney disease, applied in the field of medicine, to reduce renal fibrosis, easy to use, and protect the kidneys

Active Publication Date: 2022-01-18
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But so far there is no report on the prevention and treatment of CKD

Method used

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  • Application of jolkinolide B in preparation of drugs for preventing and treating chronic kidney diseases
  • Application of jolkinolide B in preparation of drugs for preventing and treating chronic kidney diseases
  • Application of jolkinolide B in preparation of drugs for preventing and treating chronic kidney diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The present embodiment discloses a kind of tablet that takes petogenolide B as raw material medicine, and its composition is as follows:

[0039]

[0040] Take petroglide B, mix with hydroxypropyl methylcellulose, talcum powder, lactose, and magnesium stearate, add absolute ethanol to make soft material, pass through a 24-mesh sieve, make granules, dry, add Magnesium stearate, blended, compressed into tablets.

Embodiment 2

[0042] The present embodiment discloses a kind of capsule that takes petroglyptone B as raw material medicine, and its composition is as follows:

[0043]

[0044] Take petroglide B, mix evenly with starch, dextrin, and hydroxypropyl cellulose, add absolute ethanol to make a soft material, pass through a 24-mesh sieve, make granules, dry, add magnesium stearate, and mix well. Fill into capsules.

Embodiment 3

[0046] This embodiment discloses a kind of granule that takes petroglyptone B as raw material medicine, and its composition is as follows:

[0047]

[0048] Take petroglide B, mix with sucrose, starch, talcum powder, and croscarmellose sodium evenly, add absolute ethanol to make a soft material, pass through a 24-mesh sieve, make granules, dry, and add stearic acid Magnesium, mixed well, bagged.

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PUM

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Abstract

The invention provides application of jolkinolide B in preparation of drugs for preventing and treating chronic kidney diseases. The jolkinolide B can inhibit epithelial-mesenchymal transdifferentiation by inhibiting activation of a TGF-beta / Smads pathway, thereby playing a role in kidney protection. The jolkinolide B can be used as various chronic kidney disease drugs with obstructive nephropathy and renal fibrosis as main pathological characteristics for clinical use.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of petroglide B in the preparation of drugs for the prevention and treatment of chronic kidney disease. Background technique [0002] Currently, more than 10% of people in the world suffer from chronic kidney disease (CKD), and the number of patients is increasing year by year. With the rapid increase in the prevalence of CKD in recent years, it is particularly urgent to find safer and more effective CKD drugs. [0003] Jolkinolide B (Jolkinolide B) is an abietane-type diterpenoid isolated from the root of Euphorbia fischeriana (Euphorbiafischeriana), and its structural formula is as follows: [0004] [0005] Studies have reported that Jolkinolide B induces the expression of Caspase-3 protein in MDA-MB-231 breast cancer cells through mitochondrial release of cytochrome C, which has therapeutic applications in cancer (Oncol.Rep.2012,27:1976-1980.). Jolkinol...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K36/47A61P13/12
CPCA61K31/365A61K36/47A61P13/12Y02A50/30
Inventor 续洁琨张维库张浩军阎雨赫军张佳丁康李梅
Owner BEIJING UNIV OF CHINESE MEDICINE
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