N, N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound as well as preparation method and application thereof

A technology of cyclodextrin inclusion compound and phenylacetamide, which is applied in the field of N,N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound and its preparation, and mosquito repellent products. It can solve the problems of short effective time and unfriendliness of those who are allergic to ethanol, and achieve the effect of good effect, long effective time of mosquito repellent and rich source of raw materials

Pending Publication Date: 2022-01-25
北京斯瑞朗文生物科技有限公司
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effective time of the above-mentioned low-alcohol mosquito repellent is relatively short; because there is still ethanol in the preparation formula, it is not friendly to those who are allergic to ethanol, and it is also irritating to the eyes, so the preparation needs to be further optimized and improved.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • N, N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound as well as preparation method and application thereof
  • N, N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound as well as preparation method and application thereof
  • N, N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0046] The preparation method of N,N-diethyl-2-hydroxyl-2-phenylacetamide cyclodextrin inclusion compound, the method comprises the following steps:

[0047] (1) Take part of the water and add it to the reaction bottle, start stirring, weigh the β-cyclodextrin and auxiliary materials according to the proportion, add them to the reaction bottle, and stir to completely dissolve to form a mixed solution;

[0048] (2) Add N,N-diethyl-2-hydroxy-2-phenylacetamide to the mixed solution obtained in step (1), carry out inclusion reaction under stirring for 1-24 hours, add preservative after the reaction is completed and the remaining water, stirred and dissolved, filtered and bottled to obtain the N,N-diethyl-2-hydroxyl-2-phenylacetamide cyclodextrin inclusion compound.

[0049] Wherein, the temperature of the inclusion reaction is 10-50°C; preferably, the temperature of the inclusion reaction is 20-40°C; more preferably, the temperature of the inclusion reaction is 25-35°C.

Embodiment 1

[0052] This example provides a kind of N,N-diethyl-2-hydroxyl-2-phenylacetamide cyclodextrin inclusion complex made from the following raw materials: 30wt% main ingredient N,N-diethyl-2 -Hydroxy-2-phenylacetamide, 35 wt% hydroxypropyl-β-cyclodextrin, 15 wt% excipients and 1 wt% potassium sorbate (preservative), N,N-diethyl-2-hydroxy- 2-phenylacetamide is a crystal compound; the purity of the main material is 99.9%; the auxiliary material is povidone K30, and the balance is purified water.

[0053] The preparation method of N,N-diethyl-2-hydroxyl-2-phenylacetamide cyclodextrin inclusion compound, the method comprises the following steps:

[0054] (1) Take part of the water and add it to the reaction bottle, start stirring, weigh the hydroxypropyl-β-cyclodextrin and auxiliary materials according to the ratio, add the reaction bottle, and stir to completely dissolve to form a mixed solution;

[0055] (2) Add N,N-diethyl-2-hydroxy-2-phenylacetamide to the mixed solution obtained ...

Embodiment 2

[0057] This example provides a N,N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound made from the following raw materials: 4wt% main ingredient N,N-diethyl-2 -Hydroxy-2-phenylacetamide, 10wt% of hydroxypropyl-β-cyclodextrin, 5wt% of auxiliary materials, N,N-diethyl-2-hydroxyl-2-phenylacetamide is a crystal compound; The purity of the main material is 99.5%; the auxiliary material is mannitol, and the balance is purified water.

[0058] The preparation method of N,N-diethyl-2-hydroxyl-2-phenylacetamide cyclodextrin inclusion compound, the method comprises the following steps:

[0059] (1) Take part of the water and add it to the reaction bottle, start stirring, weigh the hydroxypropyl-β-cyclodextrin and auxiliary materials according to the ratio, add the reaction bottle, and stir to completely dissolve to form a mixed solution;

[0060] (2) Add N,N-diethyl-2-hydroxy-2-phenylacetamide to the mixed solution obtained in step (1), stir at 10°C for inclusion reac...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to an N, N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound and a preparation method thereof. The N, N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound is prepared from the following raw materials: 4wt%-30wt% of a main material N, N-diethyl-2-hydroxy-2-phenylacetamide, 4wt%-40wt% of beta-cyclodextrin, 2wt%-20wt% of an auxiliary material, 0.1wt%-1wt% of a preservative and the balance of purified water. According to the N, N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound disclosed by the invention, irritant organic solvents such as alcohol are not used, and the N, N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound is relatively good in solubility and relatively safe to use. The compound can be used for repelling mosquitoes, and is good in mosquito repelling effect, long in effective time and low in eye irritation.

Description

technical field [0001] The invention belongs to the technical field of chemical industry and relates to a mosquito repellent product, in particular to an N,N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound and a preparation method and application thereof. Background technique [0002] The hot summer is the time when mosquitoes are most likely to breed. Mosquito bites on the skin not only easily cause skin redness and swelling, but also easily spread diseases, which is very troublesome. There are many mosquito repellent products on the market, mainly toilet water, Mosquito repellent, electric mosquito coils, mosquito repellent stickers and mosquito killer lamps. Mosquito killer lamps are used to kill mosquitoes with lights that attract mosquitoes, attract them to approach and cause them to be electrocuted to death. It is more environmentally friendly and efficient, but it needs to be cleaned after a long time, and it is prone to odor. Mosquito repellent p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/32A61K31/165A61P17/02
CPCA61K47/6951A61K47/32A61K31/165A61P17/02
Inventor 刘丹妮张飞宁宗超张蓓尚玉松王轲轲童薇付喜梅
Owner 北京斯瑞朗文生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap