Application of modified nano iron oxide in preparation of medicine for preventing and/or treating inflammatory bowel disease

A nano iron oxide, inflammatory bowel disease technology, applied in the field of biomedicine, can solve problems such as increased adverse reactions of patients, and achieve the effect of improving or relieving intestinal diseases and improving weight loss

Active Publication Date: 2022-02-11
THE GBA NAT INST FOR NANOTECHNOLOGY INNOVATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to systemic effects, long-term medication will lead to increased adverse reactions in patients, such as allergic reactions, diarrhea, nausea, lymphopenia, pancreatitis, etc.

Method used

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  • Application of modified nano iron oxide in preparation of medicine for preventing and/or treating inflammatory bowel disease
  • Application of modified nano iron oxide in preparation of medicine for preventing and/or treating inflammatory bowel disease
  • Application of modified nano iron oxide in preparation of medicine for preventing and/or treating inflammatory bowel disease

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Experimental program
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Effect test

Embodiment 1

[0084] The preparation of four kinds of modified nano-iron oxides of embodiment 1

[0085] raw material:

[0086] Anhydrous Ferric Chloride (CAS No.: 7705-08-0), Anhydrous Ferrous Chloride (CAS No.: 7758-94-3), Ammonia (CAS No.: 1336-21-6), Meso-2 ,3-Dimercaptosuccinic acid (CAS No.: 304-55-2), (3-aminopropyl)triethoxysilane (CAS No.: 919-30-2), L-polylysine ( CAS number: 25988-63-0), absolute ethanol, concentrated nitric acid;

[0087] (1) 30mg FeCl 3 Dissolve in 30ml deionized water to obtain solution A;

[0088] (2) 30mg FeCl 2 Dissolve in 30ml deionized water to obtain solution B;

[0089] (3) Mix the two solutions of A and B in a beaker, add 2ml of ammonia water, stir at 500 rpm and react for 30min;

[0090] (4) The magnet is placed on the outer wall of the beaker to adsorb the reacted solution, and when the iron oxide nanoparticles (about 80nm) are adsorbed around the magnet, the supernatant is discarded;

[0091] (5) Add 50ml of absolute ethanol and (5% v / v) wate...

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Abstract

The invention provides an application of modified nano iron oxide in preparation of a medicine for preventing and/or treating inflammatory bowel diseases. The modified nano iron oxide is gamma-Fe2O3 nano particles, positive electricity modified gamma-Fe2O3 nano particles, negative electricity modified gamma-Fe2O3 nano particles or polymer modified gamma-Fe2O3 nano particles. Different modifications are carried out on the nano iron oxide, so that the surfaces of the iron oxide nanoparticles have different charges and potential differences, the purpose of adsorbing different inflammatory proteins in intestinal tracts is achieved, the nano iron oxide adsorbing the inflammatory proteins is discharged out of a body, and the purpose of improving or relieving intestinal diseases is achieved. Experimental results show that the nano iron oxide with different modifications can significantly improve weight loss, disease index increase, colon bleeding, colon shortening, colonic mucosa hyperplasia and colitis response in a dextran sodium sulfate induced inflammatory bowel disease mouse model, so that the inflammatory bowel disease is treated.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of a modified nano-iron oxide in the preparation of drugs for preventing and / or treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD) is a chronic, relapsing, remitting inflammation of the small intestine and colon consisting of ulcerative colitis (UC) and Crohn's disease (CD). It is characterized by periodic abdominal pain, vomiting, fever, bloody stools, diarrhea, and weight loss, which can affect quality of life and increase the risk of colorectal cancer. Although the etiology of IBD is not fully understood, recent research suggests that IBD may be influenced by environmental, genetic, and immune factors. Impaired synthesis and release of anti-inflammatory cytokines, including interleukin (IL)-4, IL-10, and IL-11 or transforming growth factor (TGF)-beta, inflammatory cytokines, such as tumor necrosi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61K47/54A61K47/62A61P1/00A61P1/04B82Y5/00B82Y40/00
CPCA61K33/26A61K47/542A61K47/541A61K47/62A61P1/00A61P1/04B82Y5/00B82Y40/00Y02A50/30
Inventor 刘颖宁漫漫陈春英赵宇亮
Owner THE GBA NAT INST FOR NANOTECHNOLOGY INNOVATION
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