Drug fixed-point release method and device based on magnetorheological fluid

Abstract

The invention discloses a drug fixed-point release method and device based on magnetorheological fluid. The method comprises the steps that the focus position of an organism is determined; a magnetic drug targeted release device is designed and manufactured, and a magnetic field targeted drug release point is formed; the focus is overlapped with the targeted drug release point; a control magnetic field generated by the device is used for changing the rheological property of the magnetorheological fluid, so that the drug is wrapped by magnetic particles in the magnetorheological fluid; magnetorheological fluid-wrapped drugs with solid-like characteristics are applied to a body, and the solid-like magnetorheological fluid-wrapped drugs are guided to be delivered to the focus position to gather by using a gathering magnetic field generated by the device; and then the magnetic field is removed, the magnetorheological fluid is liquefied, the drug wrapped by the magnetorheological fluid is locally released at a fixed point at the focus, and the drug release time is controllable. The magnetic drug targeted release device is arranged outside the body, so that a drug delivery release point located in the body can be generated, and when a focus is located in the body, the magnetorheological fluid drug can still be delivered to the focus at a fixed point and released in a limited time.

Description

technical field [0001] The invention relates to the technical field of intelligent drug administration, in particular to a magneto-rheological fluid-based method and device for fixed-point release of drugs. Background technique [0002] For the drug targeting of diseases, especially tumors, the current main technical means include active targeting, passive targeting, physical targeting and other approaches. Among them, both active and passive targeting achieve drug aggregation in the body through certain rules to achieve targeting, such as specific recognition of molecules, deposition in menstrual blood circulation, etc. These technologies can achieve a certain degree of drug aggregation, but they all have problems such as targeting accuracy, low drug concentration levels, and large hitting areas. Physical targeting technology uses external physical environment such as temperature or magnetic field to transport and gather drugs to the lesion site. This type of technology c...

AI Technical Summary

Problems solved by technology

[0006] An object of the present invention is to provide a method for fixed-point release of drugs based on magnetorheological fluids, which aims to solve the problem in the prior art that drugs cannot be released at fixed points in deep lesions in the body under non-invasive conditions

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