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Non-aqueous slow-release drug delivery system

A drug delivery system and slow-release technology, applied in the field of pharmacy, can solve the problems of low drug availability, low bioavailability, and poor patient tolerance, achieve good application prospects, improve drug utilization, and reduce drug waste Effect

Inactive Publication Date: 2021-07-16
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above studies have a certain sustained-release effect, they all have the disadvantage of low drug availability.
[0009] Although the above systems all have certain application value, they all have disadvantages such as complex production process, low effective drug availability, high cost, high safety risk, poor patient tolerance and low bioavailability.

Method used

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  • Non-aqueous slow-release drug delivery system
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  • Non-aqueous slow-release drug delivery system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Accurately weigh 300mg of lidocaine hydrochloride, 1.0g of benzyl alcohol, 2.0g of soybean lecithin S100 and 6.2g of ethyl oleate into a pre-weighed round bottom flask, add excess ethanol, and ultrasonically dissolve the contents completely Connect the round bottom flask to a suitable rotary evaporator, evaporate under reduced pressure until the weight change of the round bottom flask shows that absolute ethanol has been removed. The flask was cooled to room temperature, 0.5 g of fish oil was added and mixed, and the obtained contents were transferred to a glass bottle to obtain Composition 1.

Embodiment 2

[0092] Accurately weigh 200mg of verapamil hydrochloride, 1.0g of egg yolk lecithin E80, 8.1g of soybean oil and 0.2g of linseed oil into a pre-weighed round bottom flask, add excess ethanol, and ultrasonically dissolve the contents completely Connect the round-bottomed flask to a suitable rotary evaporator, and evaporate under reduced pressure until the weight change of the round-bottomed flask shows that absolute ethanol has been removed. The flask is cooled to room temperature, and 0.5g of absolute ethanol is added and mixed to obtain a combination Object 2.

Embodiment 3

[0094] Accurately weigh 500mg of promethazine free base, 2.0g of benzyl alcohol, 2.5g of egg yolk lecithin E80 and 4.0g of castor oil into a pre-weighed round bottom flask, add excess ethanol, and ultrasonically dissolve the contents completely; Connect the round bottom flask to a suitable rotary evaporator, and evaporate under reduced pressure until the weight change of the round bottom flask indicates that absolute ethanol has been removed, then cool the flask to room temperature, add 1.0 g of fish oil and mix well to obtain composition 3.

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Abstract

The invention relates to a non-aqueous slow-release drug delivery system. The non-aqueous slow-release drug delivery system comprises the following components based on the total weight of the slow-release drug delivery system of about 0.1%-20% of an active agent, about 0.5%-50% of a drug solvent, about 1% to 98% of a drug slow-release agent, about 0.1% to 85% of a drug solubilizing agent, and about 0.1% to 20% of a drug effect enhancer. The non-aqueous slow-release drug delivery system provided by the invention can provide an improved slow-release effect, improve the bioavailability and enhance the curative effect. Compared with a conventional slow-release preparation, the composition provided by the invention can improve the effective bioavailability and the drug utilization rate, can reduce the drug dosage under the same drug effect, and reduces the toxic reaction risk caused by ineffective drug accumulation. The non-aqueous slow-release drug delivery system can controllably adjust the in-vivo release rate of the active agent, and provides beneficial value for clinical on-demand treatment. In addition, the drug delivery system is good in in-vivo safety, controllable in slow release effect and high in bioavailability, and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of pharmacy, and mainly relates to a non-aqueous sustained-release drug delivery system, which can provide improved sustained-release effect, improve bioavailability and enhance curative effect. Compared with conventional sustained-release preparations, the composition of the present invention can improve the effective bioavailability and drug utilization, reduce the dosage of drugs under the same drug effect, and reduce the risk of toxic reactions caused by the accumulation of invalid drugs; the non-aqueous sustained-release delivery The drug system can controllably adjust the in vivo release rate of the active agent, providing beneficial value for clinical on-demand treatment. The obtained drug delivery system has good in vivo safety, controllable sustained release effect, high bioavailability, and has good application prospects. Background technique [0002] Many active agents (such as antibiotics, bactericides, c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/12A61K47/24A61K47/14A61K47/44A61K47/10
CPCA61K47/12A61K47/24A61K47/14A61K47/44A61K47/10A61K31/138A61K31/445A61K31/245A61K31/4422A61K31/167A61K31/277A61K31/366A61K31/4365A61K31/4748A61K31/475A61K31/5415A61K9/0019A61K9/127A61K47/28
Inventor 甘勇郭仕艳孙银银
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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