High-repeatability hydrophobic paper surface-enhanced Raman substrate, preparation method thereof and application of high-repeatability hydrophobic paper surface-enhanced Raman substrate in drug detection

Abstract

The invention belongs to the technical field of analysis and detection, and provides a high-repeatability hydrophobic paper surface enhanced Raman substrate as well as a preparation method and application thereof in drug detection in order to solve the problems of poor stability, low repeatability and the like of an existing paper surface enhanced Raman scattering (SERS) substrate. The chitosan is assembled on the surface of the paper base by utilizing an electrostatic adsorption effect between the chitosan and cellulose on the surface of the paper base, so that pores on the surface of the paper base are filled, and the surface is uniform and is converted into positive electricity; then, OTS and MTS are used for conducting hydrophobic treatment on the paper base, and finally, negative charge silver nanoparticles are assembled on the surface of the paper base through the ink-jet printing technology. According to the prepared hydrophobic paper SERS substrate, the problem of poor SERS signal detection repeatability caused by non-uniform paper substrate body is greatly solved, and the stability of the paper SERS substrate is effectively improved through electrostatic interaction between the silver nanoparticles and the paper substrate. The substrate is regular in structure and low in preparation cost, and can be further applied to field detection of drug samples.

Description

technical field [0001] The invention belongs to the technical field of analysis and detection, and relates to a highly repeatable hydrophobic paper surface-enhanced Raman substrate, a preparation method thereof and an application in drug detection. Background technique [0002] In recent years, Raman spectroscopy has been widely used in fields such as single molecule, environment, food safety, biosensing, and biomedicine because it can provide detailed information on chemical structure, crystallinity, and intermolecular interactions. However, due to the small Raman scattering area of ​​most molecules to be detected, the Raman signal intensity that can be captured is weak, which greatly limits the application range of Raman spectroscopy. Surface enhanced Raman Spectroscopy (SERS) technology is developed on the basis of Raman spectroscopy. It refers to the use of rough-surfaced noble metal materials as the SERS substrate, which can significantly enhance the Raman of the sample...

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems of poor stability and low repeatability of the current paper SERS substrate, the present invention provides a highly repeatable hydrophobic paper surface-enhanced Raman substrate and its preparation method and application in drug detection. Chitosan Combined with hydrophobic treatment to prepare SERS paper substrate with high repeatability and stability, and apply it to drug sample detection

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