Application of QSER1 gene and related medicine thereof

Abstract

The invention mainly elaborates application of QSER1 protein as a biomarker for diagnosis and prognosis of multiple tumors in multiple tumors and a method. The present invention describes the diagnosis of QSER1 in predicting a variety of cancers, such as liver cancer, sarcoma, kidney cancer, gastric adenocarcinoma, pheochromocytoma and parangganglioma, pancreatic cancer, breast cancer, gastric cancer, and the like. The invention further constructs shRNA (short hairpin Ribonucleic Acid) capable of specifically interfering with QSER1 gene expression, plasmids capable of interfering with QSER1 gene expression, lentiviruses capable of interfering with QSER1 gene expression and an antibody capable of specifically recognizing QSER1. The plasmid with the specific shRNA sequence and the lentivirus provided by the invention can reduce the expression level of the QSER1 gene, so that the growth of cells and the formation of cell clone can be inhibited, the apoptosis of tumor cells can be promoted, and the plasmid and the lentivirus have great significance in diagnosis and treatment of tumors. According to research results of the invention, a kit for diagnosis and prognosis prediction of various cancers can be developed, and the kit has a wide clinical application prospect.

Description

technical field [0001] The invention relates to the field of medical biology, in particular to the use of the QSER1 gene and related medicines. Background technique [0002] An important response to cancer therapy is the induction of cell death programs. Cancer cells proliferate indefinitely by evading the process of apoptosis, leading to the death of patients. Therefore, failure to activate the cell's apoptotic program is a hallmark of cancer therapy failure. However, the signaling pathways for programmed cell death in cancer cells are often aberrant. Apoptosis is an important reason to prevent tumorigenesis. Unregulated apoptosis leads to tumor formation and diminished response to anticancer therapies. [0003] The field of molecular analysis has grown rapidly in recent years. The focus is now shifting from a few small, predictive, disease-specific, evidence-based tests to broader tests that measure changes in myriad "genes or gene products." These genomic changes ca...

AI Technical Summary

Problems solved by technology

However, due to the unknown mechanism of action of some genes, the application in tumor research and treatment has been hindered to a large extent.

Images