8 results about "Chromaffin cell" patented technology

The invention discloses a composition for regulating sleep rhythm homeostasis as well as a preparation method and application thereof. The composition for regulating the sleep rhythm homeostasis is prepared from the following components in percentage by weight: 5 to 18 percent of polydextrose, 9 to 15 percent of galactooligosaccharide, 1 to 10 percent of inulin, 0.4 to 2 percent of gamma-aminobutyric acid, 0.8 to 2.2 percent of L-theanine, 0.1 to 3.5 percent of magnesium citrate, 2 to 21 percent of semen ziziphi spinosae extract, 1 to 10 percent of poria cocos extract, 0.5 to 2 percent of pericarpium citri reticulatae extract, 0.3 to 1 percent of liquorice root extract and 15 to 40 percent of maltodextrin. 5-18% of coconut oil powder MCTs, and 0.5-2% of a lily extract. According to the application, a magnesium MCTs shell-core structure is delivered by maltodextrin to form a mitochondrial piezoelectric engine so as to improve prebiotics, promote flora metabolism efficiency and energy supply feedback, activate intestinal pheochromophilic cells and improve SLC6A4 gene expression so as to improve synthesis of 5-hydroxytryptamine in the brain and activate GABA energy neurons; meanwhile, through the spina date seed and poria cocos quantum dots and a pericarpium citri reticulatae and liquorice pi-pi stacking network, the blood-brain barrier penetration rate is greatly increased, and hypothalamic CRH release is adjusted.

The application relates to application of C-methylated high isoflavone compounds in preparation of antitumor drugs and belongs to the technical field of drug application. In order to solve the problem that the existing antitumor activity is not much reported, the application of C-methylated high isoflavone compounds in preparation of antitumor drugs is provided, the C-methylated high isoflavone compounds are selected from compounds shown in the following formula 1 or formula 2: the C-methylated high isoflavone compounds or pharmaceutically acceptable salts thereof are used as active ingredients for preparation of antitumor drugs for preventing and / or treating adrenal pheochromocytoma (PC-12) and / or human brain astrocytoma (U-87MG). The C-methylated high isoflavone compounds have the advantages of high activity and high inhibition capacity, can be extracted from polygonatum sibiricum and have good drug safety.

This invention discloses a novel application of Bifidobacterium breve CCFM1078 in relieving intestinal colic, belonging to the fields of microbial technology and pharmaceutical technology. The Bifidobacterium breve CCFM1078 provided by this invention can relieve intestinal colic in infants and young children, specifically in the following ways: (1) increasing the visceral pain threshold and reducing the frequency of defecation in rats to a certain extent; (2) reducing the number of chromaffin cells and 5-HT content in the colon of rats with intestinal colic; (3) reducing the serum TNF-α and IL-1β content in rats with intestinal colic; (4) reducing the hippocampal TNF-α and IL-6 content in rats with intestinal colic; and (5) increasing the propionic acid content in the cecal contents of rats with intestinal colic.

This invention discloses the application of Bifidobacterium longum infantis subspecies CCFM1269 in relieving colic, belonging to the fields of microbial technology and pharmaceutical technology. The Bifidobacterium longum infantis subspecies CCFM1269 provided by this invention can relieve colic in infants and young children, specifically in the following ways: (1) increasing the visceral pain threshold in rats and reducing the visceral sensitivity of rats with colic; (2) reducing the number of chromaffin cells and 5-HT content in the colon of rats with colic; (3) reducing the serum TNF-a content in rats with colic; (4) reducing the hippocampal TNF-a and IL-6 content in rats with colic; and (5) increasing the content of butyric acid and propionic acid in the cecal contents of rats with colic.

A method for enhancing 5-hydroxytryptophan secretion by enterochromaffin cells is disclosed, and the method comprises: administering a composition to a subject in need thereof, the composition comprising: a Bifidobacterium animalis subsp. lactis BB-115 strain. Herein, another method for enhancing 5-hydroxytryptophan secretion by enterochromaffin cells through administering a composition to a subject in need thereof, the composition comprising: a Bifidobacterium animalis subsp. lactis BB-115 strain, a Lactobacillus rhamnosus MP108 strain, and a Bifidobacterium longum subsp. infantis BLI-02 strain.

The application discloses a Bifidobacterium breve for relieving irritable bowel syndrome and application thereof, and belongs to the technical field of microorganisms. The application provides a Bifidobacterium breve CCFM1300 which has the effect of relieving irritable bowel syndrome, can improve the visceral pain threshold and reduce the defecation frequency, significantly reduces nerve growth factor and myosin receptor kinase A, and then reduces the number of enteric chromaffin cells and the content of 5-HT. The Bifidobacterium breve can be used for preparing medicines for preventing and treating irritable bowel syndrome, and can be used for preparing probiotic food and health products, and has a very wide application prospect.

The application introduces the image needing to be adjusted; the image is binarized, which is convenient for the calculation and processing of the image; the non-human body image pixels are removed through the maximum connected threshold extraction method; in order to remove organs such as lungs, inversion is performed, and then the maximum connected domain extraction method is used; in order to ensure that the image is a binarized image in the subsequent processing, the image is binarized; pixel edge inflation is performed; the inflated image is subtracted from the original image to obtain an image contour; the human body contour is extracted; the coplanar matrix, the center point and the variance are calculated, the direction vector of the picture is found out through the singular value decomposition method, the angle between the human body image axis and the space X, Y and Z three surfaces is calculated, the distance between the center point of the human body image and the space center point is calculated, the human body image axis vector and the space axis vector are coincided, and the human body center point and the space center point are coincided; therefore, the medical image in the incorrect position can be returned to the correct position, the user can watch more comfortably, and the subsequent operation is avoided to be affected.

The disclosure relates to a combination of biomarkers comprising at least: (i-a) one biomarker selected in each of the following group of biomarkers: Patient's age, Plasma steroids, and Urinary steroids, and at least one biomarker selected in at least one of the group of biomarkers: O-methylated catecholamines, Small metabolites, and miRNA; or (i-b) one biomarker selected in each of the following group of biomarkers: Plasma steroids, Urinary steroids, and Small metabolites, and at least one biomarker selected in at least one of the group of biomarkers: Patient's age, O-methylated catecholamines, and miRNA. The combinations of biomarkers may be used for stratifying a hypertensive patient among different hypertensive diseases comprising Endocrine Hypertension (EHT), Primary Aldosteronism (PA), Pheochromocytoma / Functional Paraganglioma (PPGL), Cushing's Syndrome (CS), and Primary Hypertension (PHT).