A kind of preparation method and application of Shuxiong tablet

A technology of Shuxue Tablets and Adrenal Gland, which is applied in the field of preparation of Shuxue Tablets, can solve the problems of large dosage, many impurities, and backwardness of patients, and achieve the effect of reducing dosage

Inactive Publication Date: 2016-03-30
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the extraction and preparation of Shuxiong Tablets using supercritical, but the method of powdering and decocting in water is rough and backward, with many impurities, resulting in excessive dosage for patients, which is inconvenient to take and seriously affects This product has been applied clinically

Method used

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  • A kind of preparation method and application of Shuxiong tablet

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 100g of Panax notoginseng, 100g of safflower, and 200g of Ligusticum chuanxiong into a CO2 supercritical extractor, use ethanol as an entrainer, the entrainer accounts for 4% by volume of the total extraction solvent, extraction pressure is 15MPa, temperature is 30°C, CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 2

[0018] Take 100g of Panax notoginseng, 100g of safflower, and 200g of Chuanxiong and add it to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 3

[0020] Take 100g of Panax notoginseng, 100g of safflower, and 200g of Chuanxiong and add it to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

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Abstract

The invention provides a preparation method of chest smoothing tablets. The chest smoothing tablets are prepared by performing supercritical extraction on 100 g of pseudo-ginseng, 100 g of safflower and 200 g of ligusticum wallichii serving as raw materials, so that the content of each raw material is greatly improved, and the dose is reduced. The invention also provides application of the chest smoothing tablets in preparation of a medicament for inhibiting the cell proliferation of rat adrenal pheochromocytoma PC-12.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Shuxiong tablets. Background technique [0002] Shuxiong Tablets are recorded in the Pharmacopoeia, the prescription is 100g of Panax notoginseng, 100g of safflower, 200g of Chuanxiong. Decoct the flowers with water twice, 1 hour each time, combine the decoction three times, filter, and let the filtrate stand for 24 hours, take the supernatant, filter, concentrate the filtrate, dry it into a dry extract, crush it into a fine powder, add three Seven fine powders, mixed evenly, made into granules, dried, pressed into 1000 tablets, coated with sugar, and ready to be obtained. Can invigorate blood circulation, dispel blood stasis, relieve pain. For blood stasis, chest pain, bruises, swelling and pain due to blood stasis; coronary heart disease, angina pectoris, arrhythmia, soft tissue contusion. [0003] In ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/286A61K9/20A61P9/10A61P29/00A61P9/06A61P35/00
Inventor 滕军刘为生尹作民张虎
Owner QINGDAO CENT HOSPITAL
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