Bifidobacterium breve CCFM1025, fermented food and application thereof

A technology of CCFM1025 and Bifidobacterium breve, which is applied in the field of microorganisms, can solve the problems of reduced synthesis and secretion of 5-HT, reduced compliance of patients taking medication, and no preventive effect, so as to relieve HPA hyperfunction and improve intestinal peristalsis function , reducing the incidence of inflammatory bowel disease and obesity
CN108949640AActive Publication Date: 2018-12-07无锡食生臻选生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
无锡食生臻选生物科技有限公司
Publication Date
2018-12-07

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Abstract

The invention relates to bifidobacterium breve CCFM1025, a fermented food and application thereof. The bifidobacterium breve CCFM1025 can be used for improving the depression-like behavior of a depression mouse, improving 5-hydroxytryptamine in the brain of the depression mouse, improving the level of 5-hydroxytryptamine and a brain-derived neurotrophic factor, reducing the level of corticosteronein serum of the depression mouse, improving the level of 5-hydroxytryptamine in the serum of the depression mouse, improving intestinal flora disturbance of the depression mouse, reducing the abundance of intestinal veillonella, improving the abundance of bifidobacterium and mycoplasmataceae, improving alpha-diversity of intestinal flora and reducing occurrence of inflammatory bowel disease and obesity. By adopting the bifidobacterium breve CCFM1025, the mRNA level of tryptophan hydroxylase in a simulated entero-chromaffin cell can be improved, the secretion volume of 5-hydroxytryptophane ofthe cell can be improved, and a precursor substance is specifically provided to synthesis of 5-hydroxytryptamine in the brain. The bifidobacterium breve CCFM1025 has a wide application prospect.
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Description

technical field

[0001] The invention belongs to the technical field of microorganisms, and in particular relates to Bifidobacterium breve CCFM1025, fermented food and applications thereof. Background technique

[0002] Depression, also known as depressive disorder, includes major depressive disorder, bipolar disorder, seasonal affective disorder, postpartum depression, etc. As a heterogeneous disease, the pathogenesis of depression has not been clearly elucidated so far. The inconsistency in response to treatment among individuals with depression makes it a growing global burden of disease. Currently, there are more than 350 million depressed patients in the world, and it is estimated that by 2030, depression will become the number one disease in the world.

[0003] There are currently two major explanations for the mechanism of depression, including dysregulation of monoamine neurotransmitters in the brain and dysfunction of the hypothalamic-pituitary-adrenal axis (HPA). ...

Claims

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