Composition with antidepressant and anti-Alzheimer's disease effect and application thereof

An anti-depression and composition technology, which is applied in the field of compositions with anti-depression and anti-senile dementia effects, can solve problems such as inconvenient medication, heavy economic burden, etc. Effects of neurotransmitter and neurotrophic factor supply

Active Publication Date: 2019-09-03
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the two diseases are mostly in a concomitant state, patients often need to take two different drugs at the same time, which is not only inconvenient to use, but also brings a heavy economic burden

Method used

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  • Composition with antidepressant and anti-Alzheimer's disease effect and application thereof
  • Composition with antidepressant and anti-Alzheimer's disease effect and application thereof
  • Composition with antidepressant and anti-Alzheimer's disease effect and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The screening experiment of embodiment 1 best compound

[0033] 1. Experimental materials and drugs

[0034] 1. Experimental equipment

[0035] Carbon dioxide incubator (Thermo 3100, American Thermo Company); biological safety cabinet (1300SERIES, A2, American Thermo Company); ultra-trace ultraviolet / visible spectrophotometer (DENOVIX DS-11, American); fluorescence real-time quantitative PCR instrument (ABScience 7500 , the United States); electronic balance (BT125, Sartorius Scientific Instrument Co., Ltd.); ultrapure water system (Nanjing Yipudayi Technology Development Co., Ltd.)

[0036] 2. Drugs

[0037] Fluoxetine was purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd. Compound to be screened: Ginseng Representative component: Ginsenoside Rb 1 , Ginsenoside Rg 1 , ginsenoside Re; representative components of polygala polygala ketone III, 3,6-diacyl sucrose ester, representative components of Acorus α-asarone, β-asarone; representative compon...

Embodiment 2

[0093] The invention is based on the screening results of functional substances of cell models such as neurotransmitters, neurotrophic factors, central nervous system inflammation, and stress stress system. Determining the best compound composition as ginsenoside Rg 1 , polygala ketone III, α-asarone and pachymic acid. Then the present invention adopts the orthogonal design of four factors and three levels to optimize ginsenoside Rg 1 The optimal dosage ratio of polygala, xanone III, α-asarone and pachymic acid is determined by animal behavior experiments. Experimental results show that by orthogonal test, the optimal composition of the component composition has been selected as ginsenoside Rg 1 3 parts, 3 parts of polygala ketone III, 0.3 parts of α-asarone, 0.1 part of pachylic acid. The specific experimental screening is as follows:

[0094] 1. Experimental materials and drugs

[0095] 1. Experimental equipment

[0096] ANY-MAZE Behavior Analysis System (ANY-MAZE Comp...

Embodiment 3

[0142] A composition with antidepressant and anti-senile dementia effects, which consists of ginsenoside Rg 1 3 parts, 1 part of polygala ketone III, 0.3 part of α-asarone, and 1 part of pachymic acid.

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PUM

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Abstract

The invention discloses a composition with antidepressant and anti-Alzheimer's disease effect and an application thereof. The composition is prepared from the following raw materials in parts by weight: 0.1-10 parts of ginsenoside Rg1, 0.1-10 parts of polygalaxanthone III, 0.1-10 parts of alpha-asarone, and 0.1-10 parts of pachymic acid. The composition has the effects of improving the depression-like behavior of the animal and enhancing the learning and memory ability of a model animal of the neurodegenerative dementia, and can be used for preparing a drug with antidepressant and anti-Alzheimer's disease effect.

Description

technical field [0001] The invention relates to a composition, in particular to a composition with anti-depression and anti-senile dementia effects and its clinical application. Background technique [0002] Depression is a disease characterized by significant and persistent low mood, accompanied by insomnia, memory loss, eating disorders and other symptoms. In severe cases, suicidal thoughts and behaviors may appear. According to the statistics of the World Health Organization, depression has become the fourth largest disease in the world, and it is estimated that by 2020, it may become the second largest disease after coronary heart disease. Depressed patients cannot adapt to society and have decreased concentration. They are high-risk groups for suicide. Its specific pathogenesis mainly includes the following hypotheses: (1) Monoamine neurotransmitter regulation disorder hypothesis: neurotransmitters 5-hydroxytryptamine, norepinephrine, dopamine, and reuptake in the syna...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/352A61K31/575A61K31/09A61P25/24A61P25/28
CPCA61K31/704A61K31/352A61K31/575A61K31/09A61P25/24A61P25/28A61K2300/00
Inventor 朱悦段金廒詹华强
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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