Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition for improving cerebral ischemia and application thereof

A composition and a technology of cerebral ischemia, applied in the field of traditional Chinese medicine, can solve problems such as the lack of good disease treatment methods and limited progress, so as to promote cerebral cortex substantive cerebral angiogenesis, improve learning and memory decline, and improve Effects of cerebral cortical blood flow

Pending Publication Date: 2022-04-05
BEIJING UNIV OF CHINESE MEDICINE
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Vascular cognitive impairment belongs to the category of "dementia" in traditional Chinese medicine. Kidney deficiency and blood stasis and phlegm obstruction are common causes of vascular cognitive impairment. The important treatment methods of traditional Chinese medicine are to invigorate the kidney, activate blood and remove blood stasis, tonify the kidney and marrow, and clear stagnant phlegm in the body , reducing neuronal damage, inhibiting inflammation, regulating lipid metabolism disorders, and improving brain dysfunction, limited progress has been made in the management of VCI and VaD, and there is no good disease-modifying therapy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition for improving cerebral ischemia and application thereof
  • Pharmaceutical composition for improving cerebral ischemia and application thereof
  • Pharmaceutical composition for improving cerebral ischemia and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0022] According to a typical embodiment of the present invention, a pharmaceutical composition for improving cerebral ischemia is provided. The raw material drug of the pharmaceutical composition includes the following components in parts by weight: 1-30 parts of ginseng, 1-30 parts of astragalus, 0-30 parts of rehmannia glutinosa, 1-30 parts of angelica, 1-30 parts of Chuanxiong, 1-30 parts of white peony 30 parts, Shichangpu 0-30 parts, polygala 0-45 parts. Preferably, the raw material of the pharmaceutical composition includes the following components by weight: 9 parts of ginseng, 9 parts of Rehmannia glutinosa, 9 parts of angelica, 9 parts of Chuanxiong, and 9 parts of white peony; or the raw material of the pharmaceutical composition includes the following parts by weight Components: 9 parts of ginseng, 9 parts of Rehmannia glutinosa, 9 parts of Chinese angelica, 9 parts of Rhizoma Chuanxiong, 9 parts of Radix Paeoniae Alba, 9 parts of Radix Astragali; 9 parts of yello...

Embodiment 1

[0032] Preparation of pharmaceutical composition Y1

[0033]Weigh 9 parts of ginseng, 9 parts of rehmannia glutinosa, 9 parts of angelica, 9 parts of white peony, and 9 parts of Chuanxiong.

[0034] The technical preparation of the pharmaceutical composition adopts a combination of traditional methods and modern methods, and the specific treatment is as follows: each medicinal material is prepared and mixed in proportion, soaked in water with 8 times its weight, soaked for 1 hour, refluxed for 1 hour, and the leachate is collected. Repeat this step, collect The leachate, the two leachates were combined, concentrated under reduced pressure to a thick paste, and a water-extracted thick paste was obtained.

Embodiment 2

[0036] Preparation of pharmaceutical composition Y2

[0037] Weigh 9 parts of ginseng, 9 parts of astragalus, 9 parts of rehmannia glutinosa, 9 parts of angelica, 9 parts of white peony, and 9 parts of Chuanxiong.

[0038] The technical preparation of the pharmaceutical composition adopts a combination of traditional methods and modern methods, and the specific treatment is as follows: each medicinal material is prepared and mixed in proportion, soaked in water with 8 times its weight, soaked for 1 hour, refluxed for 1 hour, and the leachate is collected. Repeat this step, collect The leachate, the two leachates were combined, concentrated under reduced pressure to a thick paste, and a water-extracted thick paste was obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a pharmaceutical composition for improving cerebral ischemia and application thereof. The pharmaceutical composition comprises the following raw material medicines in parts by weight: 1-30 parts of ginseng, 0-30 parts of prepared rehmannia root, 1-30 parts of angelica sinensis, 1-30 parts of ligusticum wallichii, 1-30 parts of radix paeoniae alba, 0-30 parts of rhizoma acori graminei and 0-45 parts of polygala tenuifolia. The pharmaceutical composition provided by the invention can improve learning and memory ability decline caused by cerebral ischemia, promote substantive cerebrovascular neogenesis of cerebral cortex of vascular cognitive impairment caused by cerebral ischemia, improve cerebral cortex blood flow volume of vascular cognitive impairment caused by cerebral ischemia and the like, so that the pharmaceutical composition provided by the invention can provide drug choices for preparation of cerebral ischemia drugs, and has a wide application prospect. And a working foundation is laid for clinical medication development.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a pharmaceutical composition for improving cerebral ischemia and its application. Background technique [0002] Vascular cognitive impairment (VCI) is the second most common cause of cognitive impairment. VCI, or vascular dementia, is the result of persistent impairment of blood flow to the brain. The etiology of VCI is diverse: cerebral small vessel disease, multi-infarct dementia, strategic cerebral infarcts (ie, located in critical brain regions), hemorrhages / microbleeds; vascular disease (including cerebral amyloid angiopathy), severe hypoperfusion (eg, heart failure, arrhythmia) and hereditary vascular diseases (such as autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), etc. [0003] Vascular cognitive impairment belongs to the category of "dementia" in traditional Chinese medicine. Kidney deficiency and blood stasis an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K36/888A61P9/10A61P25/08
Inventor 肖红斌方聪刘洁贾志鑫李月婷
Owner BEIJING UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com