Antibacterial compounds

A compound and alkyl technology, applied in antibacterial drugs, active ingredients of heterocyclic compounds, organic chemistry, etc., can solve problems such as morbidity, mortality and financial cost increase burden

Pending Publication Date: 2022-04-29
JANSSEN SCI IRELAND UC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The morbidity, mortality and financial costs of such infections impose an increased burden on health care systems worldwide

Method used

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  • Antibacterial compounds
  • Antibacterial compounds
  • Antibacterial compounds

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Experimental program
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example

[0243] 1. general information

[0244] melting point

[0245] Melting points were recorded using a differential scanning calorimeter DSC 1 (Mettler Toledo). Melting points were measured with a temperature gradient of 10°C / min from 25°C to 350°C. Values ​​are peak values. Use this method unless otherwise stated.

[0246] An alternative is to use an open capillary on a Mettler Toledo MP50, denoted at "MT". Using this method, melting points are measured with a temperature gradient of 10°C / min. The highest temperature is 300°C. Melting point data was read from a digital display and checked from a video recording system.

[0247] 1 H NMR

[0248] Using an internal deuterium lock and equipped with an inverted double resonance with a z-gradient ( 1 H, 13C, SEI) probe and on a Bruker Avance DRX 400 spectrometer or Bruker Advance III 400 spectrometer operating at 400 MHz for protons and 100 MHz for carbon, and on a Bruker 5mm BBFO probe equipped with a z-gradient and on a Br...

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Abstract

The present invention relates to compounds wherein the entirety is as defined in the description, and wherein these compounds can be used as medicaments, for example for use in the treatment of tuberculosis.

Description

[0001] The present invention relates to novel compounds. The present invention also relates to compounds for use as medicaments and further for use in the treatment of bacterial diseases, including diseases caused by pathogenic mycobacteria such as Mycobacterium tuberculosis. Such compounds may act by interfering with ATP synthase in Mycobacterium tuberculosis, in which cytochrome bc 1 Inhibition of activity serves as the primary mode of action. Therefore, such compounds are mainly anti-tuberculosis drugs. Background technique [0002] Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), a serious and potentially fatal infection with worldwide distribution. Estimates from the World Health Organization indicate that more than 8 million people are infected with TB each year, and 2 million people die from tuberculosis each year. In the last decade, TB cases have increased by 20% worldwide, becoming the heaviest burden in most poor communities. If these tren...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/04C07D487/04C07D513/04C07D491/147C07D498/04C07D487/14A61K31/53A61K31/5383A61P31/04A61P31/06
CPCC07D471/04C07D487/04C07D513/04C07D491/147C07D498/04C07D487/14A61P31/04A61P31/06C07D495/04C07D498/14A61K31/53
Inventor J·E·G·吉尔蒙特M·M·S·莫特M·C·维莱拉斯阿里拉G·M·J·拉门斯A·J·D·M·勒内M·L·让蒂D·A·兰普雷赫特
Owner JANSSEN SCI IRELAND UC
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