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Biological soluble microneedle patch and preparation method thereof

A soluble, micro-needle patch technology, applied in the field of biomedicine, can solve the problems of difficulty in preparing transdermal drug delivery preparations, problems with the physical and chemical properties of terazosin hydrochloride, avoid the side effects of orthostatic hypotension, and achieve good patient compliance. , reduce the effect of orthostatic hypotension

Pending Publication Date: 2021-06-11
ZHEJIANG MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the commercially available TEH preparations are tablets and capsules. Due to the physical and chemical properties of terazosin hydrochloride, it is difficult to prepare traditional transdermal preparations.

Method used

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  • Biological soluble microneedle patch and preparation method thereof
  • Biological soluble microneedle patch and preparation method thereof
  • Biological soluble microneedle patch and preparation method thereof

Examples

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Embodiment 1

[0025] The invention adopts a casting method to prepare terazosin hydrochloride soluble microneedle patches, firstly, a custom-made quadrangular pyramid metal microneedle male mold is used to prepare a corresponding PDMS negative mold, and then injection molding is used to prepare TEH soluble microneedle patches. The preparation flow chart of the TEH soluble microneedle patch is shown in figure 1 , the preparation process of the microneedle patch is as follows:

[0026] (1) Mix dimethylsiloxane and curing agent evenly according to the weight ratio of 10:1, completely cover the surface of the metal male mold, and let it stand for 30 minutes under the condition of 0.1Mpa to discharge air bubbles. Heating and curing at 40°C for 30 minutes, followed by heating and drying for 30 minutes in the order of 50°C, 60°C, 70°C, and 80°C; after cooling to room temperature, the cured PDMS mold was peeled off from the metal mold, and finally the PDMS female mold needle body was obtained. Its...

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Abstract

The invention discloses a biological soluble microneedle patch. The microneedle patch is prepared from the following raw materials in percentage by weight: 0.05-3 percent of active medicine, 0-1 percent of pH regulator, 1-30 percent of biological soluble high polymer material and 66-98.95 percent of solvent. When the biological soluble microneedle patch is applied, the base part of the patch is pressed, the needle body pierces into the skin surface layer, the barrier of the cuticle is overcome, and along with dissolution of the biodegradable matrix of the needle body, the medicine is gradually released and absorbed into the body to take effect. Compared with a needleless patch, the soluble microneedle patch has the advantages that the medicine permeation efficiency is remarkably improved, and the permeation promoting effect can be more than ten times. The microneedle is reversible in pore-forming of the skin, and the skin is basically recovered completely after 8 hours.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a biosoluble microneedle patch and a preparation method thereof. Background technique [0002] Terazosin hydrochloride (TEH) is α 1 The receptor inhibitor is a second-generation product, long-acting and selective. Its mechanism of action is to relax peripheral vascular smooth muscle, dilate peripheral blood vessels and reduce blood flow resistance, thereby producing a blood pressure-lowering effect; relax prostate and bladder smooth muscle, thereby relieving prostate pain. Symptoms such as dysuria caused by hypertrophy, so it is mainly used in the treatment of essential hypertension and benign prostatic hyperplasia (BPH). Terazosin hydrochloride can reach more than 1 / 2 of the peak blood concentration after 1 hour of oral administration, which may cause orthostatic hypotension, and then cause side effects such as dizziness and headache. Therefore, through pharmacy research, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/517A61K47/02A61K47/18A61K47/32A61K47/36A61M37/00A61P9/12
CPCA61K31/517A61K9/0021A61K47/32A61K47/36A61K47/18A61K47/02A61P9/12A61M37/0015A61M2037/0053A61M2037/0046
Inventor 叶金翠高文彦江昌照蒋秀梅王秀敏
Owner ZHEJIANG MEDICAL COLLEGE
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