SELF-ASSEMBLY PROTEIN NANOSTRUCTURES DISPLAYING PARAmyxoVIRUS AND/OR

A nanostructure, paramyxovirus technology, applied in the direction of virus/bacteriophage, virus, virus peptide, etc., can solve the problem of weak immune response and other problems

Pending Publication Date: 2022-05-13
UNIV OF WASHINGTON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] A known limitation of subunit vaccines is that the immune response elicited may sometimes be weaker than that for other types of vaccines, such as whole virus, live vaccines, or live attenuated vaccines

Method used

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  • SELF-ASSEMBLY PROTEIN NANOSTRUCTURES DISPLAYING PARAmyxoVIRUS AND/OR
  • SELF-ASSEMBLY PROTEIN NANOSTRUCTURES DISPLAYING PARAmyxoVIRUS AND/OR
  • SELF-ASSEMBLY PROTEIN NANOSTRUCTURES DISPLAYING PARAmyxoVIRUS AND/OR

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Embodiment

[0174] Expression and purification of DS-Cav1-I53_dn5B fusion protein

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Abstract

Disclosed herein are nanostructures and uses thereof wherein the nanostructures comprise a plurality of first components, each first component comprising a plurality of identical first polypeptides selected from the group consisting of I53dn5A, I53dn5A. 1, and I53dn5A. 2, or variants thereof; and a plurality of second components, each second component comprising a plurality of identical second polypeptides that are I53dn5B or variants thereof, where the plurality of first components and the plurality of second components non-covalently interact to form a nanostructure; and wherein the nanostructure exhibits a plurality of copies of one or more paramyxovirus and / or pneumovirus F proteins or antigenic fragments thereof.

Description

technical field [0001] This application claims priority to US Provisional Patent Application Serial No. 62 / 895727, filed September 4, 2019, which is incorporated herein by reference in its entirety. Background technique [0002] Vaccination is a form of treatment used to prevent or reduce the severity of infection by various infectious agents, including bacteria, viruses and parasites. The development of new vaccines has important commercial and public health implications. In particular, improved vaccines for respiratory syncytial virus (RSV) would be needed. [0003] Subunit vaccines are vaccines made from isolated antigens, usually proteins expressed recombinantly in bacterial, insect or mammalian cell hosts. Typically, the antigenic components of a subunit vaccine are selected from proteins of infectious pathogens that have been observed to elicit an innate immune response following infection, although in some cases other components of the infectious agent may be used. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/135C07K19/00C12N15/62C12N15/45A61K39/155A61P31/14
CPCC07K14/005A61K39/12A61P31/14C12N2760/18522C12N2760/18534C12N2760/18034C12N2760/18022C12N2760/18322C12N2760/18334C07K2319/735A61K2039/55555C07K14/135A61K39/155
Inventor N·P·金B·菲亚拉G·乌达J·法拉斯
Owner UNIV OF WASHINGTON
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