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Application of fritillaria isosteroid alkaloid monomer

A technology of isosteroids and alkaloids, applied in the field of isosteroidal alkaloid monomers of the genus Fritillaria, can solve the problems such as the blankness in the development of new natural drugs, relieve inflammation and pulmonary edema, widen the scope of new application diseases, The effect of filling gaps in available medication options

Pending Publication Date: 2022-06-07
SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Through the above analysis, the problems and defects of the existing technology are as follows: clinical treatment is mainly based on mechanical ventilation and liquid management, and the few effective drugs are mostly chemical drugs. There is a wide range of needs, but the development of new natural drugs in this field is still blank

Method used

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  • Application of fritillaria isosteroid alkaloid monomer
  • Application of fritillaria isosteroid alkaloid monomer
  • Application of fritillaria isosteroid alkaloid monomer

Examples

Experimental program
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Embodiment 1

[0041] 1. Materials

[0042] 1.1 Experimental animals

[0043] Seventy-two healthy SPF-grade SD male rats, 6-8W weeks old, weighing 180-200g, were provided by Chengdu Dashuo Experimental Animal Center and kept in the animal room of West China School of Pharmacy, Sichuan University.

[0044] 1.2 Reagents and instruments

[0045] 1.2.1 Reagents

[0046]

[0047] The rest of the reagents are domestic analytical grade reagents.

[0048]

[0049] 1.2.2 Instrument consumables

[0050] name supplier Eclipse E100 Digital Trinocular Video Microscope Japan Nikon Alpha-1860 UV Vis Spectrophotometer Shanghai Puyuan Instrument Co., Ltd. HS-S7320 Paraffin Microtome Shenyang Hengsong Technology Co., Ltd. RE-5203 rotary evaporator Shanghai Yarong Biochemical Instrument Factory Decompression vacuum drying oven Shanghai Yiheng Technology Co., Ltd. Varioskan LUX multi-function microplate reader Thermo Fisher Scientific, USA gel ...

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Abstract

The invention belongs to the technical field of medicines for preventing and treating acute lung injury, and discloses application of a fritillaria heterosteroid alkaloid monomer, namely application of the fritillaria heterosteroid alkaloid monomer in preparation of medicines for treating, relieving or preventing lung injury. Lung injury is acute lung injury induced by LPS. The lung injury can also be caused by influenza virus infection, bacterial infection and / or fungal infection. The fritillaria heterosteroid alkaloid monomer comprises dehydroobberidine and peimisine. The invention further discloses a preparation method of the fritillaria heterosteroid. According to the invention, corresponding representative compounds, namely dehydroobberidine and peimisine, are selected for an activity experiment for preventing and treating the acute lung injury, and the two natural small-molecule alkaloid monomers, namely dehydroobberidine and peimisine, are determined to have good activity for preventing and treating the acute lung injury, and can obviously relieve lung inflammation and pulmonary edema conditions; the new application disease range of fritillaria plants is widened, and a reliable direction and basis are provided for development of safe and effective new drugs for acute lung injury.

Description

technical field [0001] The invention belongs to the technical field of medicines for preventing and treating acute lung injury, in particular to the use of an allosteric alkaloid monomer of the genus Fritillaria. Background technique [0002] At present, acute lung injury (ALI) is a clinical syndrome characterized by dyspnea, inflammatory cell infiltration in the lung, increased pulmonary microvascular permeability, severe edema of alveoli and lung parenchyma, and progressive hypoxemia. Symptoms, the overall mortality rate is as high as 40%, is a major disease endangering human health. It is currently believed that the pathogenesis of ALI is that the body's excessive inflammatory response caused by external stimuli leads to multiple organ dysfunction syndrome. LPS-infected pneumonia is the most common pathogenic factor of acute lung injury, which will induce the secretion of various inflammatory factors in the body, causing inflammation. The system activates, triggering the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K31/4375A61K36/8966A61P11/00A61P31/16A61P31/04A61P31/10
CPCA61K31/58A61K31/4375A61K36/8966A61P11/00A61P31/16A61P31/04A61P31/10
Inventor 叶本贵贺喜
Owner SICHUAN UNIV
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