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Sterilizing gel

A technology for bactericidal gels and gels, applied in the directions of antibacterial drugs, organic active ingredients, pharmaceutical formulations, etc., can solve the problems of inconvenient use of solutions, affecting therapeutic effects, poor adhesion, etc., and achieves low cost and enhanced curative effect. , good stability

Inactive Publication Date: 2007-02-21
GUANGZHOU PUIS PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Relatively speaking, the solution is inconvenient to use and has poor adhesion, so as to affect the therapeutic effect; while the suppository and film coating are poorly tolerated by patients and sometimes contaminate clothes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] prescription:

[0023] Chlorhexidine acetate 200g

[0024] Hydroxyethylcellulose (HEC) 2000g

[0025] Ethanol (95%) 2000g

[0026] Lactic acid (L-rotary) 3g

[0027] Water 95797g

[0028] Preparation Process:

[0029] Add chlorhexidine acetate into ethanol, stir and dissolve, and place it for later use.

[0030] Add the prescribed amount of HEC into purified water, heat and stir until HEC is completely dissolved, heat to 85°C, and keep warm for 30 minutes. Stir, cool down to 60°C, add lactic acid diluted with 10 times the amount of water, and adjust the pH to 5.0-7.0; stir, cool down to 45°C, add the pre-prepared chlorhexidine acetate ethanol solution, cool down to 35°C, and stir for 30 minutes , after checking that the appearance is transparent and free of particles, the material is discharged, and the product is obtained.

Embodiment 2

[0032] prescription:

[0033] Chlorhexidine Gluconate 300g

[0034] Hypromellose (HPMC) 2000g

[0035] Ethanol (95%) 2000g

[0036] Lactic acid (L-rotary) 3g

[0037] Water 95697g

[0038] Preparation Process:

[0039] Add chlorhexidine gluconate into ethanol, stir and dissolve, and place it for use.

[0040] Add the prescribed amount of HPMC into purified water, heat and stir until the HPMC is completely dissolved, heat to 85°C, and keep warm for 30 minutes. Stir, cool down to 60°C, add lactic acid diluted with 10 times the amount of water, adjust the pH to 5.0-7.0; stir, cool down to 45°C, add the pre-prepared chlorhexidine gluconate ethanol solution, cool down to 35°C, stir for 30 Minutes, the appearance is transparent and free of particles, and then the material is discharged, that is to say.

Embodiment 3

[0042] prescription:

[0043] Chlorhexidine acetate 20g

[0044] Hydroxyethylcellulose (HEC) 2000g

[0045] Ethanol (95%) 2000g

[0046] Lactic acid (L-rotary) 3g

[0047] Water 95977g

[0048] Preparation Process:

[0049] Add chlorhexidine acetate into ethanol, stir and dissolve, and place it for later use.

[0050] Add the prescribed amount of HEC into purified water, heat and stir until HEC is completely dissolved, heat to 85°C, and keep warm for 30 minutes. Stir, cool down to 60°C, add lactic acid diluted with 10 times the amount of water, adjust the pH to 5.0-7.0; stir, cool down to 45°C, add pre-prepared chlorhexidine acetate ethanol solution, cool down to 35°C, stir for 30 Minutes, the appearance is transparent and free of particles, and then the material is discharged. That is, the gel of the present invention is obtained.

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PUM

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Abstract

The present invention relates to sterilizing gel, and sterilizing gel containing chlorhexidine or its physiologically acceptable salt as active component. The sterilizing gel contains also stuffing, excipient, synergist and pH regulator.

Description

technical field [0001] The invention relates to a bactericidal gel, in particular to a bactericidal gel containing chlorhexidine or a physiologically acceptable salt thereof as an active ingredient. technical background [0002] Women's own physiological environment is very special. The vagina and vulva are warm and humid, which is very suitable for the reproduction of various pathogenic microorganisms, resulting in various gynecological inflammations and odors. According to data, 80% of adult women will suffer from gynecological inflammation once or twice in their lifetime, the most common of which are vaginitis and cervical diseases, as well as chlamydia and mycoplasma infections. Since clean water cannot completely remove secretions and dirt, the rampage of pathogenic microorganisms is inevitable. [0003] Chlorhexidine (chlorhexidine), chemical name 1,6-bis(n-p-chlorohexidine) hexane, also known as dichlorohexidine. Belongs to the low toxicity class, difficult for the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/191A61K31/19A61K31/155A61K9/00A61P31/04
Inventor 贝庆生
Owner GUANGZHOU PUIS PHARMA FACTORY