Local anesthesia fusion spray cloth for human body local anesthesia and preparing method

A technology of local anesthesia and local anesthetics, applied in the directions of anesthetics, sheet delivery, active ingredients of heterocyclic compounds, etc., can solve the problem of long process route, and achieve the effect of reducing pain, soft hand feeling, and avoiding toxic and side effects

Inactive Publication Date: 2007-05-09
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the medical dressing is also made of fibers into medical cloth, and then made into a medical dressing, so the above-mentioned process route is still relatively long

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Raw material: polypropylene chips (non-toxic high melt index)

[0032] Melt index: 100

[0033] Local anesthetic ingredients: Tetracaine (16% added)

[0034] Melt blown screw zone temperature (°C):

[0035] Preheating zone Zone 1 Zone 2 Zone 3 Elbow flange zone

[0036] 92 165 198 205 210

[0037] Meltblown template temperature: 289°C

[0038] Hot air temperature: 310°C

[0039] Hot air pressure: 3.5kg / cm 2

[0040] Melt blown receiving cylinder temperature: 130°C

[0041] Local anesthetic injection pressure: 0.2kg / cm 2

[0042] The local anesthesia melt-blown cloth sustained-release time in saline: 8 days.

Embodiment 2

[0044] Raw material: polypropylene chips (non-toxic fiber grade)

[0045] Melt index: 48

[0046] Local anesthetic ingredients: bupivacaine (15% added)

[0047] Melt blown screw zone temperature (°C):

[0048] Preheating zone Zone 1 Zone 2 Zone 3 Elbow flange zone

[0049] 90 135 170 180 185

[0050] Meltblown template temperature: 272°C

[0051] Hot air temperature: 285°C

[0052] Hot air pressure: 2.8kg / cm 2

[0053] Melt blown receiving cylinder temperature: 115°C

[0054] Local anesthetic injection pressure: 0.18kg / cm 2

[0055] The local anesthesia melt-blown cloth sustained release time of local anesthetic in normal saline: 9 days.

Embodiment 3

[0057] Raw material: polypropylene chips (non-toxic fiber grade)

[0058] Melt index: 150

[0059] Local anesthetic ingredients: procaine (20% added)

[0060] Melt blown screw zone temperature (°C):

[0061] Preheating zone Zone 1 Zone 2 Zone 3 Elbow flange zone

[0062] 90 150 189 195 205

[0063] Meltblown template temperature: 278°C

[0064] Hot air temperature: 300°C

[0065] Hot air pressure: 3.2kg / cm 2

[0066] Melt blown receiving cylinder temperature: 120°C

[0067] Local anesthetic injection pressure: 0.32kg / cm 2

[0068] The sustained release time of the local anesthetic melt-blown cloth in normal saline: 13 days.

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PUM

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Abstract

The present invention belongs to the field of medical material technology, and provides one kind of local anesthesia fusion spray cloth for local anesthesia of human body. The local anesthesia fusion spray cloth consists of anaesthetic and non-toxic polymer fusion spray cloth as carrier. It has the features of sustained released anaesthetic, fine fusion spray cloth, soft hand feeling and less pain produced in wound and is suitable for clinical use. The present invention adopts physically adhered fusion sprayed fiber net with short high temperature operation time and less decomposition and suitable for industrial production.

Description

Technical field: [0001] The invention belongs to the technical field of medical materials. Specifically relates to a local anesthesia (local anesthesia) melt-blown cloth product and a preparation method thereof for local anesthesia of human body. Background technique: [0002] Clinically, in order to alleviate the pain of the human body due to surgical operations, burns or scalds, etc., and to avoid adverse reactions caused by pain, medical means of implementing local anesthesia (local anesthesia) in a small area of ​​the human body are usually used. The local anesthesia methods currently used include: for example, injection or intravenous injection of local anesthetics, but this method often has high toxic and side effects due to the high concentration of one-time entry into the human body, and the medical cost is high and the curative effect is short; another method is to inject Local anesthesia fibers (local hemp fibers) are made into dressings to bind or stick on the wo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/445A61K31/167A61K31/166A61K31/44A61P23/02
Inventor 邹黎明倪建华王依民赵铁侠孔维娟
Owner DONGHUA UNIV
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