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Beta-carotene clathrate and its preparation method

A carotene and clathrate technology, which is applied to the clathrate composed of β-carotene and β-cyclodextrin derivatives and the field of preparation thereof, can solve problems such as poor solubility, achieve improved solubility, facilitate industrialization and preparation The effect of simple and easy process

Inactive Publication Date: 2007-05-23
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The β-carotene inclusion compound prepared by grinding method has poor solubility

Method used

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  • Beta-carotene clathrate and its preparation method
  • Beta-carotene clathrate and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: The present invention prepares β-carotene and HP-β-CD solid clathrate

[0020] Accurately weigh 0.02g of β-carotene and HP-β-CD1g and place them together in a mortar, add 1ml of distilled water dropwise, and grind under the protection of nitrogen. After grinding for 3 hours, a red paste was obtained. Dissolve the red paste with 100ml of ethanol, stir at low speed for 6 hours at room temperature, distill off the organic solvent under reduced pressure, add distilled water to redissolve, and let stand at low temperature for 5 hours. After concentrating under reduced pressure, vacuum-dry at 50°C for 5 hours to obtain a deep red solid clathrate. The content (w / w) of β-carotene in the clathrate was determined by ultraviolet-visible spectrophotometry=1.7%, the yield=82%, and the inclusion rate=95%.

[0021] Using ultraviolet-visible spectrophotometry, it is determined that the inclusion substance in the inclusion complex is β-carotene. Extract the clathrate with D...

Embodiment 2

[0022] Example 2: The present invention prepares β-carotene and HP-β-CD solid clathrate

[0023] Accurately weigh 0.05 g of β-carotene and 0.45 g of HP-β-CD and place them together in a mortar, add 1 ml of distilled water dropwise, and grind under the protection of nitrogen. After grinding for 2 hours, a red paste was obtained. Dissolve the red paste with 50ml of ethanol, stir at low speed for 6 hours at room temperature, distill off the organic solvent under reduced pressure, add distilled water to redissolve, and let stand at low temperature for 5 hours. After concentrating under reduced pressure, vacuum-dry at 50°C for 5 hours to obtain a deep red solid clathrate. The content (w / w) of β-carotene in the inclusion compound was determined by ultraviolet-visible spectrophotometry=6.21%, the yield=82%, and the inclusion rate=97%.

[0024] Infrared spectroscopy was used to determine that the inclusion substance in the inclusion compound was β-carotene. The infrared spectrum of ...

Embodiment 3

[0025] Example 3: The present invention prepares β-carotene and SBE-β-CD solid clathrate

[0026] Accurately weigh 0.02g of β-carotene and 0.4g of SBE-β-CD and place them together in a mortar, add 1ml of distilled water dropwise, and grind under the protection of nitrogen. After grinding for 3 hours, a red paste was obtained. Dissolve the red paste with an appropriate amount of water, stir at low speed for 6 hours at room temperature, and stand at low temperature for 5 hours. After concentrating under reduced pressure, it was vacuum-dried at 35°C for 5 hours to obtain a dark red solid clathrate. The content (w / w) of β-carotene in the inclusion compound was determined by ultraviolet-visible spectrophotometry=6.4%, the yield=73%, and the inclusion rate=98.56%.

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Abstract

The invention provides a beta-carotene inclusion compound, which comprises beta-carotene and beta-cyclodextrin derivative by the weight ratio of 1:9-50. The preparing process comprises the steps of mixing beta-cyclodextrin derivative with beta-carotene, grinding 1-3 hours, dissolving with right amount of alcohol, agitating, evaporating the dissolvent and dissolving the solid inclusion compound into water, stewing 12-24 hours at a low temperature, decompression concentration, vacuum drying 3-6 hours at 35-50 deg C.

Description

technical field [0001] The invention relates to a beta-carotene inclusion compound, in particular to an inclusion compound composed of beta-carotene and beta-cyclodextrin derivatives and a preparation method thereof. Background technique [0002] β-carotene is a conjugated double bond compound, molecular formula C 40 h 56 , the molecular weight is 536.88. β-carotene is purple-red crystal or crystalline powder, odorless and tasteless, easily oxidized in air and light, soluble in carbon disulfide, benzene, chloroform, hexane and vegetable oil, insoluble in water. [0003] β-carotene plays very important physiological functions in the body. 1. β-carotene is the precursor of vitamin A, which plays an important role in maintaining the normal physiological functions of human skin and eyes. 2. It can stimulate the body's immunity and enhance immune function. 3. It is an excellent antioxidant, which can scavenge free radicals, reduce photosensitive oxidation, and prevent the fo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/557A61K47/40A61P37/04A61P39/06A61P9/10A61P35/00A61P25/28A61P31/12
Inventor 周叶红双少敏
Owner SHANXI UNIV
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