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Method to aid smoking cessation

A technology of effective dose and compound is applied in the field of helping smoking cessation, sibutramine, phenylcyclobutylamine treat patients who want to quit smoking, and prevent the weight gain of patients after smoking cessation, can solve problems such as weight gain, and achieve the prevention of smoking cessation. Effects of adverse symptoms

Inactive Publication Date: 2002-06-26
KNOLL PHARMA CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although symptoms of nicotine withdrawal, such as high anxiety, hostility, and depression, are strongest 48-72 hours after stopping smoking, people who stop smoking for a long time are at risk of weight gain and the craving to return to smoking

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The present invention will be used by patients who need to quit smoking and have set a quit date. Sibutramine 15 mg orally each morning (or 10 mg daily) was initiated within one week of the planned quit date. Continue this daily dose of sibutramine until 6 months after the planned quit date. In combination with sibutramine to provide a behavior modification program. This scenario may include individual counseling dialogues or group counseling dialogues. The attending physician visited the patients 2 weeks before the planned quit date, 1 month after the planned quit date, 3 months after the planned quit date, 6 months after the planned quit date, and 9 months after the planned quit date.

Embodiment 2

[0034] The invention is used for patients who need to quit smoking and have determined the date of quitting smoking. Sibutramine 15 mg orally every morning (or 10 mg per day) started within 2 weeks of the planned quit date. Continue this daily dose of sibutramine until 6 months after the planned quit date. In combination with sibutramine to provide a behavior modification program. This scenario may include individual counseling dialogues or group counseling dialogues. A 2-month nicotine patch was also used at the start of the planned quit date. 2 weeks before the planned quit date, 1 month after the planned quit date, 3 months after the planned quit date, 6 months after the planned quit date, and 9 months after the planned quit date, by The attending physician visits the patient.

Embodiment 3

[0036] The invention is used for patients who need to quit smoking and have determined the date of quitting smoking. Start sibutramine 15 mg orally every morning within 2 weeks of the planned cessation date. Continue this daily dose of sibutramine until 4 weeks after the planned quit date. In combination with sibutramine to provide a behavior modification program. The program included giving each patient a smoking cessation self-help pamphlet at the beginning of the program and providing them with a 5- to 10-minute lifestyle change conversation during all visits and phone calls to enhance their smoking cessation efforts. This clinical intervention, based on ACHPR principles, includes advice on successful abstinence / continuation of abstinence (e.g. abstinence from alcohol, other smokers in the home), explanation of the harms of smoking (e.g. impact on family, society, health, and previous smoking cessation experience), determine the risks of smoking (acute and long-term risks...

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PUM

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Abstract

This invention relates to a method to aid smoking cessation by treating a patient who wishes to stop smoking with an effective amount of a compound, in particular a phenylcyclobutylbutylamine, in order to aid the patient in overcoming the craving following smoking cessation. The method relates to preventing weight gain in a patient who ceases to smoke and optionally is using a nicotine patch or other agent or program to aid in ceasing to smoke.

Description

[0001] The present invention relates to methods of aiding smoking cessation. More particularly, it relates to a method of treating a patient wishing to quit smoking with an effective amount of a compound, particularly phenylcyclobutylbutylamine, to help the patient overcome the craving for smoking after quitting. Furthermore, it relates to a method of preventing weight gain in patients after quitting smoking. Background of the invention [0002] Stopping nicotine use is extremely difficult for most smokers, and many who formally seek help to quit quit smoking within a year. Although symptoms of nicotine withdrawal, such as high anxiety, hostility, and depression, are strongest 48-72 hours after stopping smoking, people who have stopped smoking for a long time are at risk of weight gain and the urge to smoke again. [0003] Because of the health side effects of smoking and the difficulty of breaking the habit completely for many smokers, it would be advantageous to find effect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P25/34A61K31/135A61K31/137
CPCA61K31/135A61P25/34A61K31/137
Inventor C·M·门德S·格拉哈姆N·罗特哈姆
Owner KNOLL PHARMA CO
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