Xiasangju effervescent tablet and its preparing process

A technology of effervescent tablets and Xiasangju, which is applied to medical preparations containing active ingredients, pill delivery, respiratory diseases, etc., can solve the problems that have not yet been seen in Xiasangju effervescent tablets, and achieve effervescent sensory novelty, good taste, The effect of high bioavailability

Inactive Publication Date: 2003-06-25
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, the Chinese patent medicine preparations mainly composed of Prunella vulgaris, mulberry leaves and wild chrysanthemum are mainly Xiasangju granules, but there are no Xiasangju effervescent tablets and related reports.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Preparation of Xiasangju Extract and Wild Chrysanthemum Volatile Oil

[0044] The dosage of the three medicinal materials is: Prunella vulgaris 1500g, mulberry leaves 525g, wild chrysanthemum 240g;

[0045] Add 12 times the amount of water to 240 g of wild chrysanthemum, and use a 5L round bottom flask with a volatile oil extractor to reflux extract for 5 hours, collect the volatile oil of wild chrysanthemum, and store it at low temperature (4°C) for future use. In addition, the water extract was filtered while hot to obtain filtrate A.

[0046] Put 1500g of Prunella vulgaris and 525g of mulberry leaves into a multifunctional extractor, and extract twice with water. Add 24 times the amount of water for the first time, extract for 1.5 hours; add 18 times the amount of water for the second time, extract for 1 hour, filter while hot, and combine the filtrates to obtain filtrate B. Combine filtrates A and B.

[0047] Concentrate the above mixed filtrate until the volu...

Embodiment 2

[0066] 1. Preparation of Xiasangju extract and volatile oil of wild chrysanthemum:

[0067] The dosage of the three medicinal materials is: 1500g of Prunella vulgaris, 300g of mulberry leaves, and 300g of wild chrysanthemum.

[0068] Add 10 times the amount of water to 300 g of wild chrysanthemum, and use a 5L round bottom flask with a volatile oil extractor to reflux extract for 6 hours, collect the volatile oil of wild chrysanthemum, and store it at low temperature (4°C) for later use. In addition, the water extract was filtered while hot to obtain filtrate A.

[0069] Put 1500g of Prunella vulgaris and 300g of mulberry leaves into the multifunctional extractor, and extract twice with water. Add 222 times the amount of water for the first time, extract for 1.5 hours; add 18 times the amount of water for the second time, extract for 1 hour, filter while hot, and combine the filtrates to obtain filtrate B. Combine filtrates A and B.

[0070] Concentrate the above mixed filt...

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PUM

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Abstract

The effervescent Xiasangju tablet contains the effective components of selfheal, mulberry leaf and wild chrysanthemum flower including the extract powder of selfheal, mulberry leaf and wild chrysanthemum flower 12-18 wt%, volatile oil of wild chrysanthemum flower 0.03-0.1 wt%, disintegrating agent comprising acid agent 15-30 wt% and alkali agent 40-60, lubricant 2-5 wt%, sweetener 0-10 wt% and perfuming agent 0-5 wt%. It is prepared through water extraction, alcohol deposition, spray drying, tablet pressing and other technological process. The effervescent tablet may be disintegrated and dissolved into homogeneous solution in three min and has the features of easy swallowing, high biological utilization, good taste, novel effervescence, etc.

Description

technical field [0001] The invention relates to a Chinese medicine preparation Xiasangju effervescent tablet containing three traditional Chinese medicine components of Prunella vulgaris, mulberry leaves and wild chrysanthemum and a preparation process thereof. technical background [0002] Effervescent tablet is a solid preparation for internal or external use that can rapidly generate air bubbles (ie, effervescent) after being placed in water to make the tablet disintegrate rapidly. Its biggest feature is that the disintegrant is based on one or several organic acids (acid agents) and one or several kinds of acids that can produce CO 2 Composed of inorganic salts (alkaline agents), which react with water to produce acid-base neutralization and release CO 2 Disintegrate the tablet. As a new type of preparation, effervescent tablets have the following characteristics: [0003] (1) Its production, transportation, and storage are in solid for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P11/00A61P31/00A61P43/00
Inventor 杨得坡胡海燕黎颖
Owner SUN YAT SEN UNIV
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