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Thermo-sensitive water-soluble high-molecular material

A water-soluble polymer and heat-sensitive technology, applied in the field of polymer materials, can solve the problems of inability to control the release of intelligent drugs, and achieve the effect of improving water solubility

Inactive Publication Date: 2003-07-16
IND TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 2. At present, there is a certain gap between the LCST of temperature-sensitive water-soluble polymers and human body temperature, at least three degrees above, which cannot be used for intelligent drug release control in the human body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take 5g monomeric N-isopropylacrylamide (NIP) and dissolve it in 35g DMF, stir slowly to make it completely dissolved. Next, 5 g of monomer 1-vinyl-2-pyrrolidone (VPD) and 0.11 g of chain transfer agent 3-mercaptopropionic acid (MPA) were added. After the temperature was raised to 70°C, 0.04 g of initiator 2,2'-azobisisobutyronitrile (AIBN) was added to react for 5 hours. Concentrate the reacted bath solution, slowly drop it into ether, and filter to obtain a light yellow powder.

[0043] The resulting copolymer (NIP:VPD=1:1 molar ratio) was dissolved in deionized water with a solid content of 20%, and the temperature was raised at a heating rate of 2°C per minute in nitrogen, and the temperature was measured by a thermal differential scanning card (DSC ) to measure LCST, and to measure its molecular weight by GPC (gel partition chromatography).

[0044] According to the above experimental procedure, another two groups of copolymers with molar ratios of NIP:VPD=2:1 an...

Embodiment 2

[0047] Take 5g monomer N-isopropylacrylamide (NIP) and dissolve it in 50g DMF, stir slowly to make it completely dissolved. Next, 5 g of monomer 1-vinyl-2-pyrrolidone (VPD), 3.185 g of acrylic acid (AA) monomer and 0.15 g of chain transfer agent 3-mercaptopropionic acid (MPA) were added. After the temperature was raised to 70°C, 0.06 g of initiator 2,2'-azobisisobutyronitrile (AIBN) was added to react for 5 hours. Concentrate the reacted solution, slowly drop it into ether, and filter to obtain a light yellow powder.

[0048] The resulting copolymer (NIP:VPD:AA=1:1:1 molar ratio) was dissolved in deionized water with a solid content of 20%, and the temperature was raised at a heating rate of 2°C per minute in nitrogen, and the thermal difference scanning method LCST was measured by calorimeter (DSC), and its molecular weight was measured by GPC (gel partition chromatography).

[0049] According to the above-mentioned experimental procedure, another two groups of copolymers w...

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Abstract

A water-soluble thermosensitive high-molecular material is a copolymer prepared from N-isopropyl acrylamide, 1-vinyl-2-pyrrolidone, and acrylic acid. It features its thermal reversible water solubility, that is, when the temp of its aqueous solution is raised to LCST, deposit occurs and when the temp is lowered, the deposit is dissolved, changing the ratio of its components can regulate the deposition temp.

Description

technical field [0001] The invention relates to a polymer material, in particular to a heat-sensitive water-soluble polymer material (thermal responsive, water-soluble polymers). Background technique [0002] Many polymer solutions have a phenomenon known as cloud point, the temperature at which solids begin to precipitate out of the polymer, making the solution appear hazy. Most of the polymer-solvent system will reduce the solubility with the decrease of temperature. However, many water-soluble polymers have the opposite phenomenon in aqueous solution, that is, the polymer will precipitate at higher temperature. Known as "lower critical solution temperature" (LCST; Lower Critical solution temperature). If the change from clarification to mist is reversible, the polymer solution can be used in a heat-sensing drug delivery system or in purifying or separating some specific substances. Such a polymer with thermoreversible water-soluble properties is a kind of so-called smar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/56C08F226/10
Inventor 林志祥陈英茂吕玟绫
Owner IND TECH RES INST
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