Use of Chinese herb peucedanum praeruptorum in preparation of medicine for treating tumor

A technology of Peucedanum chinensis and tumor drugs, which is applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulas, etc.

Inactive Publication Date: 2003-08-06
CITY UNIVERSITY OF HONG KONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine has been used to improve the general condition of cancer patients, but it has never been used for the specific eradication of MDR cancer cells

Method used

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  • Use of Chinese herb peucedanum praeruptorum in preparation of medicine for treating tumor
  • Use of Chinese herb peucedanum praeruptorum in preparation of medicine for treating tumor
  • Use of Chinese herb peucedanum praeruptorum in preparation of medicine for treating tumor

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Embodiment 1

[0023] Detailed Description of the Invention Example 1: Extraction of Active Components in Peucedanum baicalensis

[0024] Material source Peucedanum praeruptorum Dunn was purchased from Anhui Province, China, and the herbarium samples of Peucedanum praeruptorum were preserved in City University of Hong Kong, Hong Kong Special Administrative Region, China.

[0025] Extraction of active ingredients: For the convenience of the following biological experiments, the active ingredients in Baihuaqianhu are extracted. Experimental results show that 50% cold ethanol can extract the most Chinese medicine ingredients, so the effective ingredients in Baihuaqianhu The preparation steps of the extract include:

[0026] 1) pulverize the dried Peucedanum chinensis;

[0027] 2) Extract the pulverized Peucedanum pectoralis with 50% cold ethanol for 72 hours, filter the extract and

[0028] Ethanol was removed to obtain the crude product.

[0029] The crude product that uses HPLC identific...

Embodiment 2

[0029] The crude product that uses HPLC identification to obtain, its collection of illustrative plates such as figure 1 shown. Example 2: Biological experiment and analysis of the anti-tumor effect of Peucedanum baicalensis

[0030] The following biological experiments on the anti-tumor effect of Peucedanum baicalensis are all carried out with the crude ethanol extract of Peucedanum baicalensis as materials.

[0031]Cell lines and reagents Human cancer cell lines KB-3-1 and KB-V1 (MDR cells from KB-3-1 selected with vinblastine) were used. These cells were cultured in MEM (Gibco, MD, USA) containing 10% fetal bovine serum (FBS) and 1% antibiotic solution (Gibco, MD, USA), and 300ng / ml of vinblastine was added to maintain the effect on KV- Drug resistance of V1 cells. at 5% CO 2 cultured in an incubator.

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Abstract

The present invention relates to a secondary medicinal application of the Chinese traditional medicinal materials peucedanum praeruptorum. The peucedanum praeruptorum or its effective component or medicine composition containing any one of then can be used as effective component in auxiliary medicine in chemotherapy for curing tumor, said inventino can effectively inhibit the multiple drug resistance (MDR) produced by tumor cell, so that it can produce synergistic effect for chemotherapeutic medicine, also can be used as effective component in antitumor medicine, and can induce tumor cell to die to kill tumor cell so as to attain the goal of curing tumor.

Description

technical field [0001] The present invention relates to the second medical application of the traditional Chinese medicine-Baihua Qianhu, in particular to the application of Baihua Qianhu in the preparation of medicines for treating tumors. Background technique [0002] Tumor multidrug resistance (Muti-drug Resistance, MDR) is clinically considered to be the most common cause of chemotherapy failure. Chemotherapy for tumors for a long time often leads to selective survival of cancer cells, and these surviving cancer cells Cells are cross-resistant to a broad spectrum of structurally and functionally unrelated chemotherapeutic drugs. Several mechanisms that may lead to MDR include failure of cells to enter programmed death (apoptosis) due to adaptation to chemotherapy, or failure of drugs to reach or act on intracellular targets. Anti-cancer treatments such as drug therapy, biological therapy or radiation therapy must hit intracellular targets of the tumor and should subsequ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P35/00
Inventor 方宏勋胡耀昌
Owner CITY UNIVERSITY OF HONG KONG
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