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Method and system in diffused light for scatheless monitoring blood-oxygen metabolizability of biologic tissue

A technology of biological tissue and blood oxygen metabolism, applied in biological testing, scattering characteristic measurement, color/spectral characteristic measurement, etc., can solve problems affecting detection accuracy, failure to obtain results, complex system structure, etc., to improve detection accuracy and facilitate The effect of adjustment

Active Publication Date: 2004-10-27
TSINGHUA UNIV
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Problems solved by technology

In principle, applying the classical Lambert-Beer law directly under strong scattering does not yield any correct results
The method used in the publication number US005632273A is based on a semi-infinite homogeneous medium, and the steady-state spatial resolution calculation algorithm adopted by it has an impact on the detection of blood oxygen saturation in deep tissues when there is an outer layer of tissue. It is used in the patents of publication numbers CN1333011A and CN1331953A The method has no deterministic algorithm steps and detection values, and cannot accurately detect tissue blood oxygen saturation, and the weak signal affects the detection accuracy, and the system structure is complex

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  • Method and system in diffused light for scatheless monitoring blood-oxygen metabolizability of biologic tissue
  • Method and system in diffused light for scatheless monitoring blood-oxygen metabolizability of biologic tissue
  • Method and system in diffused light for scatheless monitoring blood-oxygen metabolizability of biologic tissue

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Embodiment Construction

[0039] It contains 3 infrared light sources LS distributed at different distances from the photodetector, and 1 photodetector OPUS, which are arranged in a linear manner to form a probe 8, such as Figure 6 shown. According to the multiple optical density values ​​measured at different positions, the present invention performs algebraic operation on the given empirical formula to obtain the tissue oxygen saturation in the local area. The system consists of sensors, preamplifier circuits, A / D converters, embedded microcontrollers, external SRAM, LCD displays and touch screens, such as Figure 5 shown. The microcontroller is AT89C52, the OPUS used is a silicon photocell, the liquid crystal display has a resolution of 320*240 and a touch screen of 1024*1024. look like Figure 7 As shown, the probe 8 connects the plug 9 to the instrument 10, 11 is a liquid crystal and a touch screen, and 12 is a reset button.

[0040] Typical hardware devices designed based on the principle of...

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Abstract

Three light-emitting diodes (LED), each of which can emit light containing two wavelengths, setup at three different locations emit light in sequence in time interval of 0.5ms. Photoelectric detector located at position in same side of the said three LED detects light intensity of diffused from deep tissue irradiated by LED so as to calculate out optical density OD and blood-oxygen saturation of tissue to be tested. Simple structure of the system is suitable to practical request.

Description

technical field [0001] The non-destructive monitoring method of biological tissue blood oxygen metabolism based on diffuse light belongs to the fields of spectral technology application and biomedical engineering. Background technique [0002] Monitor the blood supply of local tissues (including brain and muscle), and observe its changes over time, and monitor the survival rate of patients during surgery, critically ill patients and infants with hypoxic-ischemic encephalopathy and tissue transplantation have important meaning. [0003] To determine the oxygen metabolism status of local tissues, there are mainly direct measurement methods of invasive tissue oxygen partial pressure based on electrochemical principles and non-destructive detection methods based on optical measurement. The optical method can complete non-invasive monitoring, which is convenient, safe, stable and reliable. The present invention belongs to one of optical methods. The method described in the doc...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/145G01N21/25G01N21/47G01N33/50
Inventor 丁海曙黄岚王广志腾轶超李岳
Owner TSINGHUA UNIV
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