Application of yam total saponin in the process for preparing anti-aspirin resisting medicine

A technology of aspirin and total saponins, applied in the field of medicine, can solve the problems such as the effect that has not yet been reported

Active Publication Date: 2005-07-06
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0030] However, there is no report about the effect of diosgenin on aspirin resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] Preparation of total dioscin saponins: take 10 kg of yellow yam rhizome, heat and reflux with 95% ethanol to extract twice, concentrate the extract, add 10 L of water to dissolve, remove insoluble matter, and concentrate the aqueous solution to obtain a brown extract. Take 50 g of it for silica gel column chromatography, and use chloroform-methanol (20:1) system for gradient elution to obtain the diosgenin product. Among them, calculated as dry products, the total steroidal saponins contained in the total steroidal aglycones shall not be less than 35%.

[0112] Preparation of capsules: process the total dioscin saponins obtained by the above method into capsules to obtain.

Embodiment 2

[0114] Preparation of total dioscin saponins: Weigh a certain amount of turmeric rhizome, crush it with a grinder, add a certain amount of high-temperature amylase and a certain amount of water, stir well, put it in a super thermostat for fermentation for a certain period of time, wash with water and filter . After the filter residue was refluxed with 3mol / L hydrochloric acid for 4h and hydrolyzed with Ca(OH) 2 Neutral to neutral. After washing with water and suction filtration, it was dried, and then placed in a Soxhlet extractor to extract with petroleum ether for 6 hours. The extract was concentrated and dried to obtain the dioscin product. Among them, calculated as dry products, the total steroidal saponins contained in the total steroidal aglycones shall not be less than 35%.

[0115] Preparation of capsules: process the total saponins of dioscinia obtained by the above method into capsules, to obtain.

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PUM

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Abstract

The invention discloses the use of yam total saponin in the process for preparing anti-aspirin resisting medicine, wherein the preparation comprises water extraction, enzymolysis method or supercritical extraction method. calculated by dried article, the content of steroid glycoside is greater than 35%.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to the application of dioscin total saponin in the preparation of medicine for treating aspirin resistance. Background technique [0002] Aspirin (Aspirin), also aspirin or acetylsalicylic acid, has been used clinically for more than 80 years and is an ancient antipyretic and analgesic. In recent years, with the in-depth research on prostaglandins, new understandings have been gained on aspirin: in addition to being traditionally used for antipyretic, analgesic and anti-inflammatory, it is also used for anti-platelet aggregation in clinical practice. Clinical trials have shown that aspirin is an effective antiplatelet drug for the primary prevention of high-risk patients with cardiovascular and cerebrovascular diseases, and is also effective for the secondary prevention of myocardial infarction and ischemic vascular events. [0003] How...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/7048A61P9/10
Inventor 吴迺峰郭治忻范立君郑军郑永锋李旭
Owner TIANJIN TASLY PHARMA CO LTD
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