Nuclear factor-K B P65 subunit antagonistic peptide and its use
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
- Publication Date
- 2005-10-19
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The present invention relates to the field of medicine, in particular to a group of nuclear factor-κB (NF-κB) p65 subunit antagonistic peptides for treatment, more specifically, to a group of peptides capable of specifically binding to nuclear factor-κB p65 subunit and inhibiting it. Active small molecule peptides. The present invention also relates to the preparation and application of these nuclear factor-κB p65 subunit antagonistic peptides. Background technique
[0002] NF-κB is a transcription factor ubiquitously present in the cytoplasm of almost all cells. It is the convergence point of various signal transduction pathways and has the functions of regulating various immune responses, inflammatory responses, virus replication, cell apoptosis and proliferation and Function of growth and development-related gene expression. NF-κB is a dimeric protein composed of two Rel family proteins. According to the differences in structure, function and syn...