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Method for discerning tablets of tonifying stomach and promoting digestion

A technology of Jianweixiaoshi Tablets and Pseudostellaria Pseudostellariae, which is applied to the digestive system, medical formulas, medical preparations containing active ingredients, etc., and can solve the problem of incomplete utilization of active ingredients

Active Publication Date: 2006-01-11
JIANGZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Pseudostellaria heterophylla (Miq.) Paxex Pax et Hoffm. is the main drug in the prescription of Jianwei Xiaoshi Tablets, also known as Haier Shen ("New Ginseng in Decoction Pieces"). It is the dry root of Pseudostellaria heterophylla (Miq.) Paxex Pax et Hoffm. , the effect of promoting body fluid and nourishing the lungs. It is often used clinically for symptoms such as spleen deficiency, fatigue, loss of appetite, weakness after illness, deficiency of qi and yin, spontaneous sweating and thirst, dryness of the lungs and dry cough. Cutting it into medicine will inevitably make the active ingredients unable to be fully utilized

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription: Pseudostellaria ginseng 228.6g, yam 171.4g, tangerine peel 22.9g, malt 171.4g, hawthorn 114.3g

[0025] Preparation method 1: Take 114.3g of Pseudostellariae Radix and 171.4g of Chinese yam, grind them into fine powder, take another 22.9g of tangerine peel, 171.4g of malt, 114.3g of hawthorn and the remaining 114.3g of Pseudostellariae Pseudostellaria, add water to decoct twice, and add water 10 times for the first time For the second time, add 8 times the amount of water, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate at low temperature to a thick paste (specific gravity 1.30, 60°C), add the above fine powder and powdered sugar to make granules , dried, added magnesium stearate 16g, compressed into 1000 pieces (0.8g / piece), to obtain final product.

[0026] Preparation method 2: take 171.4g of Chinese yam, grind it into fine powder; Add 8 times the amount of water for 2 hours each time, combine the decoction, filter, a...

Embodiment 2

[0031] Prescription, preparation method are with embodiment 1

[0032] Tablets made by different methods can be identified by the following methods:

[0033] Take 3 g of tablet fine powder, add 80 ml of water, stir well, ultrasonically extract for 30 minutes, centrifuge for 15 minutes (4000 rpm), discard the supernatant, add 10 ml of water to the precipitate, stir well, ultrasonically extract for 30 minutes, and centrifuge for 15 minutes ( 4000 rev / min), get supernatant, as need testing solution.

[0034] Take 2ml of the test solution, add 2 drops of 2% ninhydrin ethanol solution dropwise, shake well, put it in a boiling water bath and heat until color develops; The prepared test product did not appear blue-purple within 4min. .

Embodiment 3

[0036] Prescription, preparation method are with embodiment 1

[0037] 1600 tablets (0.5g / tablet) were made by different preparation processes, and the following methods were used for identification: (1) Take 24 tablets, grind them finely, add 50ml of petroleum ether (60-90°C), and extract under reflux for 1 hour , filtered, the filtrate was evaporated to dryness, and the residue was dissolved in 1ml of ethyl acetate as the test solution. Take another 3.5 g of Pseudostellaria reference medicinal material, and prepare the reference medicinal material solution in the same way. According to thin-layer chromatography (Appendix VI B of Chinese Pharmacopoeia), draw 15 μl each of the above-mentioned test solution and reference drug solution, respectively spot on the same silica gel G thin-layer plate, and use cyclohexane-ethyl acetate (9: 1) As a developing agent, develop, take out, dry in the air, spray with 1% vanillin sulfuric acid solution, and heat at 105°C until the spots are ...

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PUM

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Abstract

A Chinese medicine in the form of tablets for invigorating the function of stomach and helping digestion is prepared from pseudostellaris root, tangerine peel, yam, germinated barley and haw. Its discrimination method features that the thin-layer chromatography is used to descriminate the liposoluble components of pseudostellaris root and the ninhydrin chromotest is used to discriminate its water-soluble components.

Description

technical field [0001] The invention relates to a method for identifying Jianweixiaoshi tablets made from heterophylla pseudostellariae, tangerine peel, yam, malt and hawthorn, in particular to a method for identifying Jianweixiaoshi tablets made by different preparation techniques. technical background [0002] Jianwei Xiaoshi Tablets is a standard issued by the Ministry (WS 3 -B-0379-90 and WS 3 -B-3086-98-2004) and the national drug standard (2001ZFB0022), which are composed of heterophylla, tangerine peel, yam, malt and hawthorn. The final extract is concentrated, traditional wet or dry granulation, the loss of active ingredients is large, the utilization rate is low, and the tablet appearance is rough, mouthfeel is relatively poor; 1. Preparation method: Grind yam into fine powder, decoct Pseudostellaria heterophylla, tangerine peel, malt and hawthorn with water, filter, concentrate the filtrate at low temperature into a clear paste, spray dry, add...

Claims

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Application Information

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IPC IPC(8): A61K36/36A61K36/752A61K36/8945A61K36/8998A61K36/734A61P1/14G01N30/90G01N33/15
Inventor 李诒光徐昌瑞
Owner JIANGZHONG PHARMA
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