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Capillary electrophoresis chip integrated with electrochemical detection electrode made by hot pressing method

A technology of capillary electrophoresis and detection electrodes, which is applied in the direction of material electrochemical variables, measuring devices, scientific instruments, etc., can solve the problems of low sensitivity, difficulty in integration, large instrument volume, etc., and achieve simple and easy process, convenient chip use, low cost effect

Inactive Publication Date: 2006-05-10
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Laser-induced fluorescence detection has high sensitivity, but due to the large size of the instrument, it is difficult to integrate, which is not conducive to the miniaturization of the system
Ultraviolet light absorption detection can detect a wide range of substances, but the sensitivity is low, and the light source is large, and it is difficult to integrate and miniaturize the system

Method used

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  • Capillary electrophoresis chip integrated with electrochemical detection electrode made by hot pressing method
  • Capillary electrophoresis chip integrated with electrochemical detection electrode made by hot pressing method
  • Capillary electrophoresis chip integrated with electrochemical detection electrode made by hot pressing method

Examples

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Effect test

Embodiment 3

[0024] image 3 It is a schematic diagram of embodiment 3: amperometric detection method PDMS substrate curved channel capillary electrophoresis chip.

[0025] (1) Production of the substrate: the substrate is polydimethylsiloxane PDMS, and its main process is: making the chip male mold - mixing PDMS prepolymer and curing agent in a ratio of 1: 1 - casting and curing - stripping die-bonding. For the specific method, see the invention patent 200510009804.9 "A Simple and Irreversible Bonding Method for Chips Using Polydimethylsiloxane as a Substrate".

[0026] (2) Fabrication of the cover sheet: On a substrate of the same material and size as the substrate, select a position corresponding to the substrate liquid pool, and punch a hole with a diameter of 1 mm. Embed a palladium electrode at the end of the separation channel at a distance of 1.5 mm from the buffer waste pool, and the palladium electrode is vertical to the separation channel. The amperometric working electrode i...

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Abstract

The invention relates to an electrophoresis chip of high polymer substrate capillary tubes which comprises base-plate, cover plate and metal wire detecting electrode. On the base-plate having sampling and separating micro channel, buffer solution pool and sampling pool; the metal wire being embedded on the cover plate by separating or performing as electrochemical detecting electrode; micro channel, buffer solution pool on the base-plate being made by mechanical engraving or casting molding; the base-plate and cover plate being made by heat pressing or being bond by chemical method to form electrophoresis chip. The inventive electrophoresis chip has the advantages of being used for separating and detecting mineral ions, organic molecule, amino acid and proteins.

Description

(1) Technical field [0001] The present invention relates to a polymer capillary electrophoresis microchip suitable for electrochemical detection, specifically a microchip integrated with electrochemical detection electrodes suitable for the separation and detection of small amounts of inorganic anions, cations, amino acids and other small molecules. Capillary Electrophoresis Microchip. (2) Background technology [0002] Capillary electrophoresis is a new high-efficiency separation and analysis technique. It is one of the most cutting-edge research fields in analytical chemistry. In recent years, capillary electrophoresis microchips based on MEMS technology have developed rapidly due to their advantages of less sample consumption, short separation time, easy system integration and miniaturization, and suitable for mass production, and have become a new field of rapid development of capillary electrophoresis technology. . Capillary electrophoresis microchips are manufacture...

Claims

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Application Information

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IPC IPC(8): G01N27/447G01N27/28
Inventor 刘晓为田丽王蔚张宇峰尹亮
Owner HARBIN INST OF TECH
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