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Giant knotweed rhizome active ingredient emodin extraction method

A technology of active ingredients and extraction methods, which is applied in the field of extracting emodin active ingredients from Polygonum cuspidatum by adopting a tank group countercurrent process, can solve the problems of low extraction efficiency, long extraction time, and large amount of solvent, and achieve high extraction efficiency and high extraction rate. High, extraction time saving effect

Inactive Publication Date: 2006-07-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thermal reflux and percolation extraction are the most widely used extraction techniques in the Chinese medicine industry, but these two techniques have disadvantages such as large amount of solvent, long extraction time and low extraction efficiency.

Method used

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  • Giant knotweed rhizome active ingredient emodin extraction method
  • Giant knotweed rhizome active ingredient emodin extraction method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] 1. Reverse gradient extraction

[0013] see figure 1 1. Pulverize the knotweed medicinal material, weigh a certain amount and put it into five extraction tanks, add the extraction solvent into the E tank, select 35% to 70%, 8 to 12 times the volume of ethanol solution, and the temperature rises to 35 to 65 ° C, Extract for 20-50 minutes. After the extraction is completed, transfer the extract in tank E to tank D, add fresh solvent to tank E, raise the temperature to 35-65°C, and extract for 20-50 minutes. After the extraction, transfer the extract in tank D to tank C, transfer the extract in tank E to tank D, add fresh solvent to tank E, raise the temperature to 35-65°C, and extract for 20-50 minutes . After the extraction, transfer the extract in tank C to tank B, transfer the extract in tank D to tank C, transfer the extract in tank E to tank D, and add fresh solvent to tank E , the temperature rises to 35-65°C, and the extraction takes 20-50 minutes. After the e...

Embodiment 2

[0021] Crush the medicinal material of Polygonum cuspidatum, weigh 10g each into five extraction tanks A, B, C, D, and E, add 8 to 12 times the volume, 35 to 70% ethanol solution into tank E, and raise the temperature to 35 to 70%. At 65°C, extract in stages for 20-50 minutes. Orthogonal experiment was designed, the factor levels are shown in Table 1, and the extraction was carried out according to the operating points of "reverse gradient extraction" and "countercurrent extraction". After the extraction is completed, the extracts are combined, the volume is measured, and samples are taken to analyze the content of emodin. See Table 2 for the results.

[0022]

[0023] test

Embodiment 3

[0025] (1) Optimum tank group countercurrent process extraction

[0026] Crush the medicinal material of Polygonum cuspidatum, weigh 10g each into five extraction tanks A, B, C, D, and E, add 10 times the volume, 70% ethanol solution to tank E, raise the temperature to 65°C, and extract in stages for 35 minutes . Extract according to the operating points of "reverse gradient extraction" and "countercurrent extraction". After the extraction is completed, the extracts are combined, the volume is measured, and samples are taken to analyze the content of emodin.

[0027] (2) Hot reflux extraction

[0028] Weigh 10g of Polygonum cuspidatum into a 250mL round bottom flask, add 100mL of 70% medicinal alcohol, install a condenser, reflux at 90°C for 2 hours, cool rapidly, filter and separate the medicinal material from the extract, and add 100mL of 70% medicinal alcohol, continue to reflux for 2 hours, combine the extracts, and measure the emodin content in the extracts.

[0029] ...

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Abstract

The invention provides a method for extracting the effective component archin of the giant knotweed rhizome, which puts the drugs into five extracting tanks after shattering them to in turn extract the E, D, C, B, A tank with the extracting solution: 30%-70% alcohol whose amount is 8-12 volume of the drug's quality, the temperature: 35-65 deg. and the time: 20-50 minutes, so that the effect component of the extracting solution of the five tanks descendent, it then discharges opeing the tank which has the highest effect component and discharges the dross of the tank which has been five solution extracted, it dose interval removal to the other extracting solution and dose four cycles and then amalgamates the extracting solutions.

Description

technical field [0001] The invention belongs to the field of extraction of effective components of natural medicines, and relates to a method for extracting emodin from medicinal material Polygonum cuspidatum, in particular to a method for extracting effective components of emodin from Polygonum cuspidatum by adopting a tank group countercurrent process. Background technique [0002] Shujin Fengshi wine is a kind of medicinal wine mainly made of medicinal materials such as Polygonum cuspidatum, Millet Spatholobus, and Shui Gaoli, soaked in white wine and extracted. It has the functions of dispelling wind dampness and relaxing tendons and collaterals. It is mainly used for rheumatic arthralgia, bruises, muscle and bone pain, soreness of the waist and limbs and other diseases. After research, its main medicinal ingredient is emodin in Polygonum cuspidatum. Emodin has obvious inhibitory effects on Staphylococcus aureus, Escherichia coli, and Shigella flexneri, inhibits the pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C7/00C07C15/27
Inventor 陈勇刘雪松谢志鹏蔡铭程翼宇
Owner ZHEJIANG UNIV
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