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Pharmaceutical composition for treating bone diseases and method for preparing the same

A composition and technology for bone diseases, applied in drug combinations, bone diseases, pharmaceutical formulations, etc., can solve gastrointestinal irritation and other problems, achieve the effect of less side effects, safe clinical medication, and no adverse reactions

Active Publication Date: 2006-07-26
哈尔滨圣泰生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the other medicines are single chemical synthetic medicines and single traditional Chinese medicine extracts, most of which are solid preparations in dosage form, and long-term use is irritating to the gastrointestinal tract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Extract 50 kg of clean pig limb bones with 100 liters of pure water for 1 hour respectively, extract twice in total, combine the extracts, concentrate the extracts to 1 / 3 in volume, and adjust the pH value to 3.5±0.2, 10 with dilute hydrochloric acid solution in turn. Adjust the pH to 9.0±0.2 with % sodium hydroxide solution, wash and precipitate with 80% ethanol, recover the ethanol, then filter, and the filtrate is set aside.

[0041] Wash 20kg of dried melon seeds, break them, and extract them with 160, 120, and 80 liters of pure water for 3 times, each time for 50 minutes, combine the extracts, concentrate the extracts to 1 / 3, filter, and dilute the filtrate with ethanol Wash and recover ethanol, wash with water, wash with ethanol again and recover ethanol, wash with water, filter, and the filtrate is set aside.

[0042] Mix the two filtrates, heat to a slight boil and then cool, filter, ultrafilter, add 22500mL of water for injection, add 45g of 0.2% activated carb...

Embodiment 2

[0045] Get 60kg of clean pig limb bones and 30kg of dried melon seeds, and prepare the injection according to the method of Example 1. Among them, the acid is dilute hydrochloric acid, adjust the pH value to 3.5±0.2; the base is 10% sodium hydroxide, adjust the pH value to 9.0±0.2; wash and precipitate with 75% ethanol ethanol, recover ethanol, then filter, and the filtrate is used for later use; Add 29100mL of water, add 58g of 0.2% activated carbon, filter, adjust the pH of the solution to be between 6.5 and 7.0, take a sample to detect the polypeptide content, carry out dilute mixing according to 6mg / ml, carry out semi-finished product inspection, filling, sterilization, light inspection ,Package. Each injection has a volume of 2mL and contains 12mg of polypeptide.

Embodiment 3

[0047] Get 40kg of clean pig limb bones and 10kg of dried melon seeds, and prepare the injection according to the method of Example 1. Among them, the acid is dilute hydrochloric acid, and the pH value is adjusted to 3.5±0.2; the alkali is 10% sodium hydroxide, and the pH value is adjusted to 9.0±0.2; wash and precipitate with 85% ethanol, recover the ethanol, then filter, and the filtrate is set aside; wash the melon seeds The ethanol concentrations of the extract are [(alcohol content up to 70%) and (alcohol content up to 80%)]; add 16200mL of water for injection, add 0.2% activated carbon 32g, filter, and adjust the pH of the solution to 6.5-7.0 During the period, samples were taken to detect the peptide content, diluted and stirred according to 6mg / ml, semi-finished product inspection, filling, sterilization, light inspection, and packaging were carried out. The volume of each injection is 5mL, containing 30mg of polypeptide.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating orthopaedic diseases, especially the injection of the pharmaceutical composition and its preparation, the medicament is prepared from bone extract of pig's limbs and sweet melon seeds extract through conventional methods for injection preparation.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating bone diseases and a preparation method thereof, especially an injection preparation and a preparation method thereof. Background technique [0002] Clinically common bone diseases, such as rheumatoid arthritis, rheumatoid arthritis, and degenerative osteoarthritis and other arthritis, ankylosing spondylitis, cervical spondylosis, lumbar disc herniation, and osteoporosis, are Bone disease is a common disease that plagues patients. It is not easy to treat, and it is easy to relapse, which causes a great burden on patients physically and psychologically. [0003] Clinically, rheumatoid arthritis and joint pain caused by rheumatoid arthritis are generally treated with analgesics, non-steroidal anti-inflammatory drugs or hormone drugs. These drugs can really improve the condition and control the development of the disease, but they have obvious side effects, adverse reactions occur from tim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/42A61K35/32A61P19/08A61P19/02A61P29/00
Inventor 高翔
Owner 哈尔滨圣泰生物制药有限公司
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