3 results about "Bone joint disorders" patented technology

The invention relates to the technical field of transdermal drug delivery systems and osteoarticular disease treatment, and discloses a soluble double-layer microneedle loaded with anti-knee osteoarthritis active ingredients. The first anti-knee osteoarthritis composition is composed of a first water-soluble polymer matrix and a first anti-knee osteoarthritis active component dispersed in the first water-soluble polymer matrix; the backing layer is laminated on the base part of the needle tip layer and is composed of a second water-soluble polymer matrix and a second anti-knee osteoarthritis active component dispersed in the second water-soluble polymer matrix; and the pH responsive drug release unit is embedded in the needle tip layer and is composed of a copolymer of dimethylaminoethyl methacrylate and methacrylic acid. Through the double-layer structural design of the needle tip layer and the backing layer, the technical problem that the existing single-layer microneedle structure cannot realize staged release of medicines is solved, and the defect of short duration caused by quick release of all medicines or delayed effect caused by slow release of all medicines is avoided.

The invention relates to the field of biomedical engineering and regenerative medicine, in particular to a method for activating the homing potential of bone joints of stem cells induced by small molecules and application, and the homing potential of the stem cells is remarkably enhanced by adopting the synergistic effect of three core factors, namely SDF-1alpha, TGF-beta and vitamin D. Through induction treatment, the expression of stem cell surface homing related molecules CXCR4 and Integrin beta is remarkably improved, so that the directed migration and repair capability of the stem cell surface homing related molecules CXCR4 and Integrin beta to a damaged bone joint area is enhanced. In-vitro and animal experiment results show that the activated stem cells show a remarkable repairing effect in histological, functional recovery and iconography detection, the knee joint motion range and the cartilage thickness are remarkably improved, and the homing rate reaches 40%-60%. The method is simple and convenient to operate, does not need gene modification, provides a new cell treatment scheme for osteoarticular diseases, and has a wide clinical application prospect.

This invention relates to the fields of medical image processing and artificial intelligence diagnosis, specifically to an intelligent screening and progression monitoring system for early imaging of bone and joint diseases. The system includes an image acquisition module, an image preprocessing module, an automatic disease identification module, a differential geometry analysis module, a curvature flow evolution module, a multi-scale feature extraction module, a disease progression analysis module, and a data storage module. The differential geometry analysis module constructs the bone and joint surface as a Riemannian manifold, calculates the Gaussian curvature and mean curvature distribution, and generates a differential geometry feature map. The curvature flow evolution module constructs a curvature flow model characterizing the morphological evolution of the bone and joint surface over time, predicting morphological change trends. The multi-scale feature extraction module achieves multi-scale representation through Laplace spectral decomposition, calculates thermal kernel descriptors and wave kernel descriptors, and generates multi-scale lesion feature vectors. This invention enables early and accurate screening of bone and joint diseases, quantitative analysis of lesions, and dynamic progression prediction.