5 results about "Bone joint disorders" patented technology

The invention provides a pharmaceutical composition for bone joints as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following components in parts by weight: 20 to 2000 parts of N-acetylglucosamine and 10 to 1000 parts of non-denatured type II collagen. In the compound composition of the N-acetylglucosamine and the non-denatured type II collagen, the two core components play a complementary role: the N-acetylglucosamine is focused on promoting synthesis of a cartilage matrix and provides a material basis for cartilage repair; the non-denatured type II collagen reduces damage of autoimmune response to cartilage through immunoregulation, the non-denatured type II collagen and the non-denatured type II collagen have a synergistic effect, the symptoms such as arthralgia and swelling can be relieved, the joint structure can be improved from the double angles of repairing and protecting, and particularly the treatment effect on patients with severe osteoarthritis is remarkably superior to that of a single-component preparation; and an innovative and efficient choice is provided for the treatment of osteoarticular diseases.

The invention discloses a bone tissue thickness determination method and device, electronic equipment and a storage medium, and the method comprises the steps: obtaining a to-be-segmented craniofacial CBCT image, and segmenting a target bone tissue from the craniofacial CBCT image; smoothing the region where the target bone tissue is located, and if the target bone tissue has a cavity region, rendering and filling the cavity region of the target bone tissue as required; and measuring or calculating the thickness of a target position of the target bone tissue area, or obtaining a thickness chromatogram of the target bone tissue, so as to determine the thickness of the target bone tissue. According to the method, the target bone tissue can be segmented, the thickness of the target bone tissue can be measured or calculated, related diseases can be further predicted or prevented according to the thickness information, a prevention scheme is provided for orthodontic bone windowing and bone cracking in stomatology, and calculation indexes are provided for bone joint diseases and bones in clinical medicine.

The invention relates to the technical field of transdermal drug delivery systems and osteoarticular disease treatment, and discloses a soluble double-layer microneedle loaded with anti-knee osteoarthritis active ingredients. The first anti-knee osteoarthritis composition is composed of a first water-soluble polymer matrix and a first anti-knee osteoarthritis active component dispersed in the first water-soluble polymer matrix; the backing layer is laminated on the base part of the needle tip layer and is composed of a second water-soluble polymer matrix and a second anti-knee osteoarthritis active component dispersed in the second water-soluble polymer matrix; and the pH responsive drug release unit is embedded in the needle tip layer and is composed of a copolymer of dimethylaminoethyl methacrylate and methacrylic acid. Through the double-layer structural design of the needle tip layer and the backing layer, the technical problem that the existing single-layer microneedle structure cannot realize staged release of medicines is solved, and the defect of short duration caused by quick release of all medicines or delayed effect caused by slow release of all medicines is avoided.

The invention relates to the field of biomedical engineering and regenerative medicine, in particular to a method for activating the homing potential of bone joints of stem cells induced by small molecules and application, and the homing potential of the stem cells is remarkably enhanced by adopting the synergistic effect of three core factors, namely SDF-1alpha, TGF-beta and vitamin D. Through induction treatment, the expression of stem cell surface homing related molecules CXCR4 and Integrin beta is remarkably improved, so that the directed migration and repair capability of the stem cell surface homing related molecules CXCR4 and Integrin beta to a damaged bone joint area is enhanced. In-vitro and animal experiment results show that the activated stem cells show a remarkable repairing effect in histological, functional recovery and iconography detection, the knee joint motion range and the cartilage thickness are remarkably improved, and the homing rate reaches 40%-60%. The method is simple and convenient to operate, does not need gene modification, provides a new cell treatment scheme for osteoarticular diseases, and has a wide clinical application prospect.

This invention relates to the fields of medical image processing and artificial intelligence diagnosis, specifically to an intelligent screening and progression monitoring system for early imaging of bone and joint diseases. The system includes an image acquisition module, an image preprocessing module, an automatic disease identification module, a differential geometry analysis module, a curvature flow evolution module, a multi-scale feature extraction module, a disease progression analysis module, and a data storage module. The differential geometry analysis module constructs the bone and joint surface as a Riemannian manifold, calculates the Gaussian curvature and mean curvature distribution, and generates a differential geometry feature map. The curvature flow evolution module constructs a curvature flow model characterizing the morphological evolution of the bone and joint surface over time, predicting morphological change trends. The multi-scale feature extraction module achieves multi-scale representation through Laplace spectral decomposition, calculates thermal kernel descriptors and wave kernel descriptors, and generates multi-scale lesion feature vectors. This invention enables early and accurate screening of bone and joint diseases, quantitative analysis of lesions, and dynamic progression prediction.