101 results about "Bone joint disorders" patented technology

Provided is a nutrient composition for promoting collagen production, which contains vitamin C, an iron preparation, and collagen as active ingredients, promotes collagen production in a living body such as skin or bone, prevents or treats skin aging or bone and joint diseases, and is an iron preparation-containing composition having stability imparted thereto. Also provided are a food or beverage, a feed, and a medicine each containing the nutrient composition incorporated therein.

The invention discloses a traditional Chinese medicine composition for the treatment of cervical spondylopathy and osteoarticular diseases and a preparation method thereof. The traditional Chinese medicine composition mainly consists of the following bulk drugs: cassia twig, Chinese angelica root, ledebouriella root, rhizome of Sichuan lovage, notopterygium, peppermint, root of kudzuvine, chrysanthemum flower, Chinese ephedra, capsule of weeping forsythia, dandelion, radix angelicae pubescentis, cortex moutan, lindera root, nutagrass flatsedge rhizome, auckandia root, red peony root, white peony root, root bark of barbary wolf berry, red sage root, tetrandra root, acanthopanax bark, bark of eucommia, achyranthis bidentatae, indian bread, magnolia bark, atractylodes rhizome, alisma rhizome, plantain seed, medicated leaven, atractylodes macrocephala, bark of chinese cassia tree, dried ginger, pricklyash berry, clove, curcuma root, corydalis tuber, safflower, peach kernel, motherwort, bighead atractylodes rhizome, raw milkvetch root, asiabell, glehnia root and boxthorn. The traditional Chinese medicine composition can obviously improve cervical spondylopathy and symptoms such as spondylopathy contraction, shoulder irritation, arthralgia, muscular tension, muscular fatigue, muscular acid bilge, dizziness, cephalalgia, soreness of the waist and the knees and pain in the legs and numbness of the extremities of other osteoarticular disease patients. The traditional Chinese medicine composition has stable efficacy, and moreover has advantages of quick effect, sustained effect, applicability to long-term use, low cost, no toxic-side effects and the like.

The invention relates to a medicine for the treatment of bone and joint diseases and the preparation method, the invention is prepared by the raw materials with the following mixing ratio of parts by weight: 20 to 40 parts of clematis root, 15 to 30 parts of Szechuan lovage rhizome, 15 to 30 parts of danshen root, 5 to 20 parts of incised notopterygium rhizome, 5 to 20 parts of doubleteeth pubescent angilica root, 20 to 40 parts of Chinese angelica, 15 to 30 parts of safflower, 15 to 30 parts of common clubmoss herb, 10 to 25 parts of common floweringquince fruit, 15 to 35 parts of garden balsam stem, 10 to 35 parts of twotooth achyranthes root, 15 to 30 parts of rhubarb, 15 to 35 parts of slenderstyle acanthopanax bark, 10 to 35 parts of beautiful sweetgum fruit, 5 to 15 parts of Chinese honeylocust abnormal fruit, 10 to 25 parts of yanhusuo, 15 to 35 parts of Chinese starjasmine stem, 15 to 35 parts of sargentgloryvine stem, 10 to 35 parts of ovientvine, 10 to 35 parts of Ningpo yam rhizome, 25 to 40 parts of kudzuvine root, 20 to 35 parts of herba siegesbeckiae, 5 to 20 parts of manchurian wildginger, 5 to 20 parts of red paeony root, 10 to 25 parts of malaytea scurfpea fruit, 5 to 30 parts of fructus litseae, 5 to 35 parts of pine nodular branch, 5 to 25 parts of pricklyash peel and 10 to 35 parts of argy wormwood leaf. The invention has good efficacy on various bone and joint diseases, no toxicity or side effects, so the invention has very good market prospect.

The invention relates to a medicinal medicament for treating osteoarthrosis which comprises the following constituents: drynaria, frankincense, safflower, achyranthes and cyathula root, Ligusticum wallichii, Clematis chinensis, ledebouriella root, notopterygium root, pubescent angelica root, myrrh, and large-leaf gentian root, the preparing process comprises proportioning, mixing homogenously, charging water by the weight ratio of 1:4, boiling for 1 hour, filtering and extracting.

A medical wine for treating rheumatic arthritis and osteoarthritis is prepared from 28 Chinese-medicinal materials including safflower, scorpion, tangerine peel, Chuan-xiong rhizome, etc through proportional mixing, crushing, immersing in liquor and filtering.

The present invention relates to one kind of externally applied plaster for treating osteoarthrosis caused by wind, cold and damp. The plaster is prepared with clematis root, spatholubus stem, yam rhizome, large-leaf gentian root, ledebouriella root and other Chinese medicinal materials, and through alcohol extraction to obtain extracted solution, adding matrix and other steps. It has the functions of relaxing muscles and tendons, promoting blood circulation, dispersing blood clots, dispelling cold, eliminating wind and damp, etc. It is used in treating arthritis, protrusion of cervical intervertebral disc, protrusion of lumbar intervertebral disc, spur, sciatica, etc. and has high curative effect.

The invention discloses a pet food. The pet food is characterized in that on the basis of the total weight of the pet food, the pet food is composed of 75-85% by weight of a main material and 15-25% by weight of an auxiliary material, wherein the main material comprises 60-85% by weight of meat on the basis of the total weight of the main material; and the auxiliary material comprises 0.3-8% by weight of hyaluronic acid on the basis of the total weight of the auxiliary material. The invention also discloses a method for preparing the pet food. The pet food contains the hyaluronic acid, and thepet food with balanced nutrition is obtained through the mutual synergistic effect among the components, so that the anorexia of a pet can be improved, the fur of the pet can be smooth, and the bonejoint disease can be improved.

The invention discloses a bone joint spatial angle measurement and function evaluation method and device. The method comprises the following three stages, wherein in the first stage, somatosensory interaction equipment is utilized to acquire bone joint depth information, and a bone joint spatial angle is calculated; the second stage, wherein according to a bone joint spatial angle measurement method in the first stage, through a K-mean clustering algorithm, classification of patients suffering from different bone joint diseases is completed; the third stage, bone joint function visible analysis and evaluation are conducted. According to the bone joint spatial angle measurement and function evaluation method and device, constraint of a traditional medical image imaging technology is shaken off, bone joint point coordinates can be obtained in real time, the angle of the bone joint is measured, updating of the largest joint flexion and extension angle of a figure in a natural activity state is completed, digital analysis and health evaluation of bone joint functions are presented for a user in a visible mode, and a more objective and effective basis is provided for medical staff on determination of a diagnosis and treatment scheme, comparison and evaluation on functions before and after treatment and guidance on rehabilitation.

The invention relates to a physiotherapy product, in particular to a physiotherapy belt for treating cervical osteoarthritis, lumbar osteoarthritis and osteoarthritis. The physiotherapy belt comprises a fixing belt on the outmost layer, wherein a magnetic fiber cloth belt layer, a nanoscale bamboo charcoal fiber material layer and a heating layer are tightly attached on a treating part on the inner side of the fixing belt from the inner part to the outer part in sequence. The physiotherapy belt has the advantages of no need of a power supply because of heat from infrared rays of a heating material and bamboo charcoal heat fiber, absolute safety, simple product structure, portability in any occasions, and no interference in activities and work. The physiotherapy belt has the effects of activating blood and dissolving stasis, freeing channels and quickening network vessels, and dispersing swellings and relieving pain, and has quick response, good effect and low recurrence rate of osteoarthritis such as the cervical osteoarthritis and the lumbar osteoarthritis.

The invention relates to medicinal liquor for treating rheumatic arthralgia and osteoarthrosis, which is prepared by soaking 20 to 30g of pubescent angelica root, 30 to 40g of divaricate saposhnikovia root, 5 to 30g of centipede, 5 to 30g of scorpion, 25 to 30g of long-noded pit viper, 15 to 20g of earthworm, 10 to 30g of Chinese polyphaga, 30 to 35g of schizophragma integrifolium, 20 to 30g of nux vomica, 30 to 35g of frankincense, 25 to 30g of myrrh, 30 to 35g of pedate pinallia jackinthepulpit rhizome, 20 to 30g of swordlike atractylodes rhizome, 15 to 25g of sargentgloryvine stem and 20 to 30g of cassia twig in each 1,000g of white spirit. The medicinal liquor has the effects of activating collaterals and relieving pain, dispelling wind and dampness, and relieving spasm and dissipating cold, can radically treat the osteoarthrosis such as the rheumatic arthralgia and the like and does not have any side or toxic effect.

The invention discloses a self-heating typed medical treatment device to mate cervical vertebra and lumbar vertebrae disease, which is composed of self-heating physical therapy belt and traditional Chinese medicine liquid, wherein the self-heating physical therapy belt contains external fixing belt and heating cloth sewed on the external fixed belt; one contacting plane of heating cloth and body possesses several heating particles, which is made of tourmaline, germanite, medical stone, embedding agent and epoxy resin; the raw material of medical liquid concludes notoginseng, chuanxiong rhizome, chiretta, notopterygium root, dried ginger, rumarin and borneol.

The invention relates to traditional Chinese medicine for eliminating pain and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine for eliminating pain is prepared from such raw materials as musk, safflower carthamus, panax notoginseng, dragon's blood, incised notopterygium, ligusticum wallichii, asarum sieboldii, peach kernel, radix angelicae, cassia twig and the like by independently soaking, steaming, fermenting and distilling in groups and mixing. The traditional Chinese medicine disclosed by the invention has beneficial effects that the traditional Chinese medicine for eliminating pain is prepared from natural Chinese herbal medicines through a fermentation process; the traditional Chinese medicine, which can be smeared on or sprayed to an affected part, can rapidly permeate skin so as to accelerate tissue repair, relieve capillary dilation, cell edema, soft tissue injury, local inflammation and like problems, to effectively improve local edema, pain or dermal inflammation, provide nutrition to tissue cell regeneration or soft tissue recovery, offer effective help to bone joint lubrication and cell reconstruction, significantly shorten recovery time in patients with bone and joint diseases and relieve the feeling of pain.

The cell death inhibitor comprising a substance capable of binding to macrophage migration inhibitory factor is useful as a preventive / therapeutic agent for, e.g., heart diseases, neurodegenerative diseases, cerebrovascular diseases, central nervous infections, traumatic diseases, demyelinating diseases, bone / joint diseases, kidney diseases, liver diseases, myelodysplastic diseases, arteriosclerosis, diabetes, pulmonary hypertension, sepsis, inflammatory bowel diseases, autoimmune diseases, failure accompanying rejection in organ transplantation, AIDS, cancer, etc.

The invention provides a collagen oral liquid with improved bioavailability, comprising bioabsorbable collagen and a stabilizer capable of promoting dispersion of the collagen. The collagen oral liquid provided by the invention contains higher content of the bioabsorbale collagen, wherein the molecular weight of the bioabsorbale collagen is from 2500D to 3500D and the content of the bioabsorbale collagen is no less than 10% (g / ml). The stabilizer capable of promoting dispersion of the collagen adopted by in the invention is selected from hydroxypropyl methyl cellulose (HPMC), sodium alginate, sodium carboxymethyl cellulose, methyl cellulose, xanthan gum and non-ionic surfactant, wherein the non-ionic surfactant contains aliphatic chains and the hydrophile-lipophile balance (HLB) value of the non-ionic surfactant is from 7 to 13. The collagen oral liquid provided in the invention is used to improve skin condition and prevent bone joint diseases.

The present invention is directed to a method of using compounds of Formula (I) to inhibit Cathepsin B. Specifically the compounds of the present invention are useful as therapeutic agents for the treatment of tumor invasion, metastasis, Alzheimer's Disease, arthritis, inflammatory diseases such as chronic and acute pancreatitis, inflammatory airway disease, and bone and joint disorders, including osteoporosis, osteoarthritis, rheumatoid arthritis, psoriasis, and other autoimmune disorders, liver fibrosis, including liver fibrosis associated with HCV, all types of steatosis (including non-alcoholic steatohepatitis) and alcohol-associated steatohepatitis, non-alcoholic fatty liver disease, forms of pulmonary fibrosis including idiopathic pulmonary fibrosis, pathological diagnosis of interstitial pneumonia following lung biopsy, renal fibrosis, cardiac fibrosis, retinal angiogenesis and fibrosis / gliosis in the eye, schleroderma, and systemic sclerosis. The compounds of Formula (I) are also useful for treating subjects with both HCV and fibrosis in a mammal, particularly liver fibrosis, and subjects affirmatively diagnosed or at risk for both HCV and liver fibrosis.

The invention discloses an osteoproliferation, osteoarticular diseases and traumatic injury treatment plaster, aiming to provide an osteoarticular plaster with high efficiency, rapid effect and obvious analgesic function. The plaster is prepared by decocting incised notopterygium rhizome, divaricate saposhnikovia root, radix glycyrrhizae preparata, cortex cinnamomi, earthworm, radix astragali, scorpion, scolopendra, radix gentianae macrophyllae, malaytea scurfpea fruit, fruit of Chinese wolfberry, herb of shorthorned epimedium, south dodder seed, largehead atractylodes rhizome, safflower, all-grass of desertliving cistanche, herb of manyspike chloranthus, root of lobed kudzuvine, ramulus cinnamomi, radix angelicae sinensis, peachseed, radix paeoniae rubra, szechuan lovage rhizome, suberect spatholobus stem, caulis piperis kadsurae, bark of oriental variegated coralbean, east asian tree fern rhizome, radix achyranthis bidentatae, rhizoma drynariae, kusnezoff monkshood root, aconite root, root of bunge pricklyash, harlequin glorybower leaf and twig, leaf of Japanese creeper, China alangium, root of wintersweet, root of longtube ground ivy herb, comphortree root, radix millettiae speciosae, all grass of pungent litse, climbing groundsel herb, root of Japanese orixa, Laportea bulbifera (sieb. et zucc.) wedd., cortex eucommiae, borneol, camphor, menthol, clove oil, musk, Chinese eaglewood, red lead and the like by conventional method. The plaster has functions of expelling wind and dampness, promoting blood circulation to remove blood stasis, nourishing liver and kidney, relieving swelling and pain, warming channels and expelling cold and the like.

The invention provides a traditional Chinese medicine for treating bone and joint diseases and a preparation method thereof, comprising the following components: 3-10 parts of Aconitum aconitum, 3-10 parts of Aconitum aconitum, 5-15 parts of Shenjincao, and 5 parts of Sperantospermia ‑15 parts, 10‑20 parts of Gallispaulis, 10‑20 parts of Qingfengteng, 10‑20 parts of Sea Breeze, 10‑20 parts of Notopterygium, 10‑20 parts of Duhuo, 5‑15 parts of Chuan Achyranthes bidentata, 5 parts of Huai Achyranthes bidentata -15 parts, 10-20 parts of cassia twig, 10-20 parts of mulberry branch, 15-25 parts of wine rhubarb, 10-20 parts of aconite, 10-20 parts of papaya, 5-15 parts of cinnamon, 10-20 parts of myrrh, 10‑20 parts of Frankincense, 7‑17 parts of Wulingzhi, 5‑15 parts of Puhuang, 5‑15 parts of Chuanxiong, 15‑25 parts of Xugufeng, 5‑15 parts of Radix Paeoniae Rubra, 15‑25 parts of Rhododendron. It has the advantages of relaxing tendons and promoting blood circulation, dispelling wind and dampness, dispelling cold and dredging collaterals, reducing swelling and relieving pain, etc. It is suitable for various bone and joint diseases.

The invention discloses a percutaneous absorption preparation for treating a bone joint disease, which relates to the technical field of medical preparations. The percutaneous absorption preparation is prepared from a D-glucosamine hydrochloride, sea cucumber lyophiled powder and medical auxiliary materials according to a specified mixture ratio. Active ingredients in the D-glucosamine hydrochloride and sea cucumber lyophiled powder are used for treating the bone joint disease in a synergetic way, and directly enter blood circulation of bone joint positions quickly at high flux; and the percutaneous absorption preparation has quick response and a good treatment effect, is environment-friendly, acts for a long time and does not cause rebounding.

The present invention provides compounds or salts thereof that regulate the activity of a protein comprising an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: 13, and antisense polynucleotides comprising a nucleotide sequence, or a part thereof, complementary or substantially complementary to the nucleotide sequence of a DNA encoding a protein, or a partial peptide thereof, comprising an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: 13. These compounds, salts and antisense poly nucleotides may be used as prophylactic and / or therapeutic agents for bone and / or arthropathy diseases such as arthritis.

The invention discloses a new method for preparing low-molecular chondroitin sulfate. The new method includes the steps that chondroitin sulfate products with the common molecular weight serve as raw materials, are degraded through electron beam irradiation and are dissolved and subjected to ultrafiltration after degradation, and the products are dried to obtain the low-molecular chondroitin sulfate. In the technology process that the low-molecular chondroitin sulfate is prepared from coarse chondroitin-sulfate materials, as multiple links such as enzyme preparation adding and chemical agent adding are replaced with pure physical means such as irradiation degradation, the technology process is simplified, the purity and the quality consistency of the product are improved, the problem that the environment is polluted in the enzymatic degradation preparing process and the chemical degradation preparing process is solved, the average molecular weight of the product is smaller than 10,000 Da, and the obtained product has the important effect on keeping the integrity of tissues. At present, the chondroitin sulfate serves as medicine and a dietary supplement to be widely applied to osteoarticular diseases, cardiovascular and cerebrovascular diseases and ophthalmic diseases.

The invention provides an externally applied Chinese medicament for treating rheumatism, osteopathy and various pains, and overcomes the defects that the prior western medicaments for treating pains by anesthesia and are easy to addict, and the Chinese medicaments have no medicaments with excellent effect recognized by people. The externally applied Chinese medicament is prepared from the following medicinal materials in portion by weight: 2 to 4 portions of prepared common monkshood daughter root, 1 to 3 portions of garden balsam stem, 1 to 3 portions of sargentodoxa stem, 0.5 to 1.5 portions of manchurian wildginger, 1 to 3 portions of cassia bark, 2 to 4 portions of fish poison yam, 1 to 3 portions of corydalis root, 1 to 3 portions of common burreed rhizome, 1 to 3 portions of zedoary, 1 to 3 portions of rhizoma atractylodis, 2 to 4 portions of beautiful sweetgum fruit, 2 to 4 portions of unprocessed semen strychni, 1 to 3 portions of kudzuvine root, 1 to 3 portions of tangkuei tail, 1 to 3 portions of safflower, 1 to 3 portions of peach seed, 2 to 4 portions of pubescent angelica root, 2 to 4 portions of incised notopterygium rhizome, 1 to 3 portions of raw arisaema root, 1 to 3 portions of twotooth achyranthes root and 2 to 4 portions of rhubarb. The invention has the advantages that the invention provides a Chinese medicament for treating pains which has remarkable curative effect and convenient taking, and is particularly suitable for various rheumatism syndromes, osteoarthritis, stomachache, bellyache, gynecopathy, and the like.

The invention discloses medicinal liquor for treating cervical spondylosis, lumbar intervertebral disc protrusion and osteoarticular diseases and relates to the medicinal liquor for treating cervical spondylosis, lumbar intervertebral disc protrusion and osteoarticular diseases. The medicinal liquor comprises the following traditional Chinese medicinal materials in a weight ratio: bungarus parvus, radix aconite, radix aconiti agrestis, sinkiang arnebia root, radix clematidis, cassia twig, garden balsam stem, scorpion, Chinese starjasmine stem, kadsura pepper stem, caulis spatholobi, herba epimedii, distilled spirit and brown sugar. A preparation method of the medicinal liquor comprises the following steps of: A, selecting the above high-quality traditional Chinese medicinal materials, removing impurities and cleaning for later use; B, cooking the traditional Chinese medicinal materials by using vapor until the traditional Chinese medicinal materials are boiled; C, drying in the sun or baking; D, placing the traditional Chinese medicinal materials, the distilled spirit and the brown sugar into a sealed bottle, uniformly mixing and sealing for 7 days. The medicinal liquor has the beneficial effects that the treatment cycle is short, one treatment course lasts for 10 days and both symptoms and root causes are treated. 312 cases prove that the total effective rate reaches 98.4%.

The invention provides a traditional Chinese medicinal composition for curing osteoarthritis and a preparation method thereof. The traditional Chinese medicinal composition is prepared from the following crude drugs, by weight, 10-20 parts of Poria cocos, 5-15 parts of polyporus, 5-15 parts of rhizoma alismatis, 5-15 parts of fried atractylodes, 5-15 parts of Plantain seed, 5-15 parts of artemisia capillaries, 3-9 parts of phellodendron, 5-15 parts of Radix Codonopsis, 5-15 parts of clematis root and 5-15 parts of seatung bark. The composition has functions of invigorating spleen, excreting dampness, clearing heat, alleviating water retention and activating meridians to stop pain. It is verified and proved through clinical tests that the traditional Chinese medicinal composition has significant effects of relieving pain and swelling symptoms of patients with osteoarthritis in the stage of attack, improving the function of the knees, raising life quality of patients and delaying progression of osteoarticular diseases such as osteoarthritis and the like. In addition, the traditional Chinese medicinal composition has little toxic and side effect, and costs are low.