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Calf serum deprotein oral cavity ointment and its preparation method

A calf serum, deproteinized technology, applied in the directions of ointment delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. The effect of poor adhesion, moderate viscosity and simple preparation method

Active Publication Date: 2006-08-30
JINZHOU AHON PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Water injections and capsules are administered systemically and cannot be applied locally; gels are used locally, but the existing gels have poor adhesion and the matrix is ​​a water-soluble substance. If used for local application in the oral cavity, the retention time is very long. short, does not have the desired effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1, the preparation of calf serum deproteinized oral ointment

[0017] To produce 1,000 calf serum deproteinized mouth creams (calf serum deproteinized extract dry powder content: 0.1%, equivalent to calf serum deproteinized extract containing 2.5%), the specific process includes the following steps:

[0018] 1. Preparation of calf serum deproteinized extract dry powder

[0019] Prepare calf serum deproteinized extract dry powder under sterile conditions. The specific method is: take venous blood from Northeast purebred yellow cattle aged 1-6 months, centrifuge at 4000rpm and 4°C for 15 minutes to separate serum; take 5L serum, add 10L of 96% ethanol, stirring constantly, let stand for 60 minutes to denature and precipitate the protein, then centrifuge at 20,000rpm, 4°C for 30min, discard the precipitate, obtain 12.5L of supernatant, use vacuum rotary evaporator, 37°C, 1 atmosphere pressure decompression Remove ethanol; add 1.5g complex protease to the remain...

Embodiment 2

[0024] Embodiment 2, the preparation of calf serum deproteinized oral ointment

[0025] To produce 1,000 calf serum deproteinized mouth creams (calf serum deproteinized extract dry powder content: 0.2%, equivalent to 5% calf serum deproteinized extract), the specific process includes the following steps:

[0026] 1. Preparation of calf serum deproteinized extract dry powder

[0027] Prepare calf serum deproteinized extract dry powder under sterile conditions. The specific method is: take venous blood from Northeast purebred yellow cattle aged 1-6 months, centrifuge at 4000rpm and 4°C for 15 minutes to separate serum; take 5L serum, add 10L of 96% ethanol, stirring constantly, let stand for 60 minutes to denature and precipitate the protein, then centrifuge at 20,000rpm, 4°C for 30min, discard the precipitate, obtain 12.5L of supernatant, use vacuum rotary evaporator, 37°C, 1 atmosphere pressure decompression Remove ethanol; add 1.5g complex protease to the remaining liquid, h...

Embodiment 3

[0032] Embodiment 3, the preparation of calf serum deproteinized oral ointment

[0033] The specific process of producing 1000 calf serum deproteinized oral ointment (calf serum deproteinized extract dry powder content: 0.4%, equivalent to containing calf serum deproteinized extract 10%) includes the following steps:

[0034] 1. Preparation of calf serum deproteinized extract dry powder

[0035] Prepare calf serum deproteinized extract dry powder under sterile conditions. The specific method is: take venous blood from Northeast purebred yellow cattle aged 1-6 months, centrifuge at 4000rpm and 4°C for 15 minutes to separate serum; take 5L serum, add 10L of 96% ethanol, stirring constantly, let stand for 60 minutes to denature and precipitate the protein, then centrifuge at 20,000rpm, 4°C for 30min, discard the precipitate, obtain 12.5L of supernatant, use vacuum rotary evaporator, 37°C, 1 atmosphere pressure decompression Remove ethanol; add 1.5g complex protease to the remain...

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PUM

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Abstract

A deproteinized oral cream of calf serum is prepared proportionally from the deproteinized extract powder of calf serum, anesthone, carboxymethyl cellulose sodium, pectin, hydroxyphenyl ethylester, menthol, atoleine and white vaseline. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a biochemical drug oral ointment preparation and a preparation method thereof. Background technique [0002] At present, the pharmaceutical dosage forms of deproteinized calf serum extract include water injection, gel and capsule, among which water injection is the most widely used. Water injections and capsules are administered systemically and cannot be applied locally; gels are used locally, but the existing gels have poor adhesion and the matrix is ​​a water-soluble substance. If used for local application in the oral cavity, the retention time is very long. Short and not as effective as it should be. Contents of the invention [0003] The object of the present invention is to provide a kind of oral ointment which uses calf serum deproteinized extract as active ingredient. [0004] Calf serum deproteinized oral ointment provided by the present invention, its formula comprises the following components in parts by weight:...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/16A61K9/06A61P1/02A61K31/245
Inventor 王洪新于鸿儒
Owner JINZHOU AHON PHARM CO LTD
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