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Compound formula dextro methaphen oral disintegration tablet and its preparation method

A technology for oral disintegrating tablets and dextromethorphan, which is applied in the field of medicine and its preparation, can solve the problems of high difficulty in powder coating process, increase in manufacturing process, increase in production cost and the like, achieve short disintegration time, improve effectiveness, low cost effect

Inactive Publication Date: 2006-09-13
SINOPHARM ZHIJUN (SHENZHEN) PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because granule coating needs to adopt expensive fluidized bed equipment, and the operation time is long, usually need more than 8 hours, thereby resulting in higher production cost; Orally disintegrating tablets, due to the difficulty of the powder coating process of drug raw materials, resulting in high production costs
③ The orally disintegrating tablets prepared by separate granulation methods disclosed by Beijing Zhongxi Jingwei Release Technology Co., Ltd. (publication number: CN 1476826A) respectively increase the manufacturing process by separate granulation methods, resulting in an increase in production costs

Method used

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Embodiment Construction

[0021] The present invention is described in further detail below in conjunction with embodiment. The weight ratio composition of the compound dextromethorphan orally disintegrating tablet of the present invention is: 0.8%-4.0% of dextromethorphan, 0.15%-1.0% of chlorpheniramine, 2.0%-12.0% of pseudoephedrine, and 15.0% of β-cyclodextrin ~35.0% or ion exchange resin 10.0%~30.0%, mannitol 40.0%~59.0% or lactose starch 45.0%~80.0%, disintegrant 4.0%~15.0%, sodium lauryl sulfate 0%~1.0% , magnesium stearate 0% to 1.5%, glyceryl behenate 0% to 1.5%, flavoring agent 0.1% to 3.0%, coloring agent 0% to 1.5%.

[0022] The preferred weight ratio composition of the compound dextromethorphan orally disintegrating tablet of the present invention is: dextromethorphan 1.0%-3.5%, chlorpheniramine 0.2%-0.8%, pseudoephedrine 2.5%-10.0%, β-cyclodextrin 20.0% %~35.0% or ion exchange resin 10.0%~25.0%, mannitol 45.0%~59.0% or lactose starch 50.0%~80.0%, disintegrant 4.0%~13.0%, sodium lauryl sul...

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Abstract

An oral disintegrating tablet of dextromethorphan for treating the cold caused cough, nasal congestion and rhinorrhea is proportionally prepared from dextromethorphan, chlorphenamine, pseudoephedrine, beta-cyclodextrin or ion exchange resin, mannitol or lactose starch, and disintegrant through sieving, flavouring, mixing and die pressing.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a compound dextromethorphan orally disintegrating tablet and an industrially applicable preparation method thereof. Background technique [0002] Medication for the elderly and infants has long been an important issue of concern to medical workers. With the improvement of people's living standards, especially with the development of my country's aging society, this problem has become more and more prominent. In recent years, orally disintegrating tablets, as a new type of oral solid preparation, have provided great convenience for solving this problem. [0003] An orally disintegrating tablet is a tablet that disintegrates or dissolves quickly in the mouth. Usually the disintegration time is several seconds to tens of seconds, generally not more than 1 minute. There is no need for additional water in the mouth, and the suspension or solution can be formed only by ...

Claims

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Application Information

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IPC IPC(8): A61K31/435A61K9/20
Inventor 闫志刚曾环想王磊罗炳锋
Owner SINOPHARM ZHIJUN (SHENZHEN) PHARMA CO LTD
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