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Ginsenoside F1 medicinal uses

A technology of ginsenosides and medicines, applied in the field of medicine, can solve the problems of difficult patient acceptance and high operation cost, and achieve the effect of less side effects

Inactive Publication Date: 2006-10-04
海口绿科南药研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main treatment for cataract is surgery, but the cost of surgery is high and it is not easily accepted by patients

Method used

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  • Ginsenoside F1 medicinal uses

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0052] Preparation Example 1 Ginsenoside F 1 Preparation

[0053] 500mg ginsenoside Re and 150mg naringinase were dissolved in 50ml phosphoric acid-citrate buffer (pH 4.5, ionic strength 0.01M, containing 10% ethanol), and hydrolyzed in a 40℃ water bath for 7 days; the reaction solution was centrifuged Collect the precipitate; wash the precipitate with 10ml water, wash 3 times (10ml×3), combine the washing liquid with mother liquor, and concentrate to 50ml for reuse; wash the precipitate with 10ml ethanol, wash 5 times (10ml×5), combine the ethanol solution, Evaporate and collect the residue to obtain ginsenoside F 1 301mg. Determination of Ginsenoside F by HPLC 1 The content is 63%.

preparation example 2

[0054] Preparation Example 2 Ginsenoside F 1 Preparation

[0055] 500mg ginsenoside Rg 1 , 150mg naringinase was dissolved in 50ml glycine-HCl buffer (pH 4.5, ionic strength 0.01M, containing 10% dimethyl sulfoxide), hydrolyzed in a water bath at 40℃ for 7 days; the reaction solution was centrifuged to collect the precipitate ; Wash the precipitate with 10ml of water, wash 3 times (10ml×3), combine the lotion and mother liquor, and concentrate to 50ml for reuse; Wash the precipitate with 10ml of ethanol, wash 5 times (10ml×5), combine the ethanol solution and evaporate to dryness , Collect the residue to get ginsenoside F 1 325mg. Determination of Ginsenoside F by HPLC 1 The content is 84%.

preparation example 3

[0056] Preparation Example 3 Ginsenoside F 1 Preparation

[0057] 500mg ginsenoside Re and Rg 1 The mixture, 150mg naringinase was dissolved in 50ml acetic acid-sodium acetate buffer (pH 4.5, ionic strength 0.01M, containing 10% formamide), hydrolyzed in a water bath at 40℃ for 7 days; the reaction solution was collected by centrifugation Precipitation; Wash the precipitate with 10ml of water, wash 3 times (10ml×3), combine the lotion with mother liquor, and concentrate to 50ml for reuse; Wash the precipitate with 10ml of ethanol, wash 5 times (10ml×5), combine the ethanol solution, steam Dry and collect the residue to get ginsenoside F 1 310mg. Determination of Ginsenoside F by HPLC 1 The content is 69%.

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Abstract

Disclosed is the use of Ginsenoside F1 in preparing medicament for the treatment of cataract.

Description

Technical field [0001] The present invention relates to the field of medical technology, specifically ginsenoside F 1 (ginsenoside F 1 ) For medical purposes. [0002] [0003] Ginsenoside F 1 [0004] Molecular formula: C 36 H 62 O 9 Molecular weight: 638.87 Background technique [0005] Ginseng (Panax ginseng C.A.Mey.) is the root of Araliaceae ginseng, which is distributed in the deep mountains of Heilongjiang, Jilin, Liaoning and northern Hebei. As a common Chinese herbal medicine, it was first published in the "Shen Nong's Materia Medica" in the Han Dynasty and was listed as the top grade. Ginseng is warm in nature, sweet and slightly bitter in taste, and has the effects of nourishing vitality, solidifying body fluids, nourishing the mind and soothe the nerves. It can be used to treat fatigue and collapse, lack of appetite, fatigue, nausea and vomiting, slippery stool, cough and shortness of breath, spontaneous sweating, panic, forgetfulness, dizziness, headache, impotenc...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P27/12
Inventor 吴巍滕厚雷
Owner 海口绿科南药研究开发有限公司
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