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Traditional Chinese medicine prepn. used for treating apoplexia and obstruction of qi in the chest, and its prepn. method

A traditional Chinese medicine preparation and a technique for thoracic paralysis, which are applied in the field of traditional Chinese medicine preparations and their preparation, can solve the problems of large dosage, rough preparation, and unsatisfactory product efficacy, and achieve the effects of prolonged drug release time lag and easy swallowing.

Active Publication Date: 2006-11-15
SHANDONG BUCHANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, capsules cannot fully meet the needs of both doctors and patients, especially capsules are not easy to swallow, are easily affected by gastric acid, and take large doses.
In addition, the applicant found in practice that the curative effect of the obtained product was not satisfactory due to the crude technology provided in the original patent application documents.

Method used

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  • Traditional Chinese medicine prepn. used for treating apoplexia and obstruction of qi in the chest, and its prepn. method
  • Traditional Chinese medicine prepn. used for treating apoplexia and obstruction of qi in the chest, and its prepn. method
  • Traditional Chinese medicine prepn. used for treating apoplexia and obstruction of qi in the chest, and its prepn. method

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Effect test

Embodiment 1

[0054] Embodiment 1: get prescription quantity medicinal material, adopt steam distillation or co 2 Supercritical extraction of the volatile oils in Chuanxiong, Angelica, Guizhi, Frankincense, and Myrrh; extracting active substances from Earthworm, Scorpion, and Hirudo by percolation; Achyranthes knuckles, Mildew Spatholobus and several herbs and steam distillation or co 2 The medicinal dregs after supercritical extraction are decocted with water to extract water-soluble active ingredients, and then alcohol precipitation is used to remove water-soluble impurities such as starch, mucilage, and gums, and finally an appropriate amount of Rudragil RS100 or Rudragil L100 or shellac is added to make pellets .

Embodiment 2

[0055] Embodiment 2: Take the prescribed amount of medicinal materials, Chuanxiong, Angelica, Guizhi, Frankincense, Myrrh coarse powder co 2 Supercritical extraction of volatile oil, percolation of scorpion, leech and earthworm with ethanol, and collection of percolation liquid for later use; take salvia miltiorrhiza, red peony root, astragalus root, safflower, peach kernel, mulberry branch, achyranthes bidentata, milletus spathii and co 2 The medicinal materials after supercritical extraction are combined, decocted with water, the filtrate is concentrated under reduced pressure and alcohol precipitated, the supernatant and percolation liquid are combined, concentrated under reduced pressure, spray-dried to obtain a dry powder for later use; the above-mentioned volatile oil is evenly sprayed on the dry powder, Then sieve and mix with an appropriate amount of lactose and microcrystalline cellulose (MCC), add a certain amount of ethanol liquid to make a wet material, and extrude ...

Embodiment 3

[0056] Embodiment 3: Take prescription amount medicinal materials, Rhizoma Chuanxiong, Angelica, Guizhi, Frankincense, Myrrh Coarse Powder CO 2 Supercritical extraction of volatile oil, extraction pressure 25Mpa, dynamic extraction at 40°C for 4h, CO 2 The flow rate is 2L / kg medicinal materials / h. After immersing scorpions, leeches, and earthworms in 60% ethanol for 24 hours, percolation is carried out at a speed of 5ml / min / kg, and the percolation fluid is collected for later use. Salvia miltiorrhiza, red peony root, astragalus root, safflower, peach kernel, mulberry branch, achyranthes bidentata, millet root and CO 2Combine the medicinal materials after supercritical extraction, add 8 times the amount of water, soak for 3 hours, decoct twice for 2 hours and 1.5 hours respectively, combine the decoction, concentrate under reduced pressure until the relative density is 1.05 at 60°C, add 95 % ethanol until the alcohol content of the liquid is 65%, let it stand for 24 hours, abs...

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Abstract

A Chinese medicine in the form of micropills for treating apoplexy and Qi obstruction of chest is prepared from 12 Chinese-medicinal materials including astragalus root, red sage root, Chinese angelica root, Chuan-xiong rhizome, etc. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine preparation for treating apoplexy and chest obstruction and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Stroke and chest obstruction are cardiovascular and cerebrovascular diseases, which are common and frequently-occurring diseases that seriously endanger human health, especially the health of middle-aged and elderly people. At present, there is no good curative drug. On August 20, 2001, in the name of Zhao Buchang, the applicant submitted a patent application entitled "A Chinese Medicine Capsule and Its Preparation Method for Treating Stroke and Chest Disorders" to the China Patent Office, and filed in 2003 It was made public on April 2, 2009, with the publication number 1406609. It is a capsule made of 16 Chinese herbal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61K9/16A61K35/62A61K35/646A61P9/10
Inventor 赵涛
Owner SHANDONG BUCHANG PHARMA
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