Preparation method of 2-(4'-methyl benzene sulfonyl) ethyl propionate

A technology of methylbenzenesulfonic acid group and ethyl propionate, applied in the direction of organic chemistry, etc., can solve the problems of low recovery rate of triethylamine, slow reaction speed, large environmental pollution, etc., to reduce pollution and labor, improve The effect of reaction speed and production cost reduction

Inactive Publication Date: 2006-11-29
陈克付
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Problems solved by technology

[0005] At present, the synthesis of ethyl 2-(4'-methylbenzenesulfonate)propionate basically adopts the traditional triethylamine process, which not only has the defects o

Method used

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  • Preparation method of 2-(4'-methyl benzene sulfonyl) ethyl propionate
  • Preparation method of 2-(4'-methyl benzene sulfonyl) ethyl propionate

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Embodiment Construction

[0010] Put 870kg petroleum grade toluene and 435kg industrial grade sodium hydroxide (NaOH) or potassium carbonate (K 2 CO 3 ) or calcium oxide (CaO), turn on the cooling water to stir and drop in 250kg of p-toluenesulfonyl chloride with a content of 99.5%, and add 186kg of p-toluenesulfonyl chloride with a content of 99.5% to the reaction kettle dropwise below 10°C. For L-ethyl lactate, continue the insulation reaction for 2-5 hours after the dropwise addition, until the reaction residue of p-toluenesulfonyl chloride is basically zero. After the reaction is over, add 600kg of water to the system, stir and dissolve, then pass to the distillation pot, and keep Use industrial hydrochloric acid to adjust the pH value of the system to 6-7 at room temperature, and then distill the toluene under negative pressure after removing the lower layer of water. base) ethyl propionate. The content reaches 98%, and the yield is ≥97%. Its chemical formula is as follows:

[0011]

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Abstract

A process for preparing 2-(4'methylbenzosulfonyl) ethyl propionate includes such steps as adding toluene, P-toluene sulfuryl chloride and sodium hydroxide or potassium carbonate or CaO into reactor, dripping ethyl L-lactate at a temp lower than 10 deg.C, reaction, adding water, stirring, regulating pH=6-7, removing lower-layer water, and negative-pressure distilling to remove toluene and obtain product.

Description

Technical field: [0001] The present invention relates to a kind of production technology of herbicide intermediate, be specifically related to a kind of preparation method of ethyl 2-(4'-methylbenzenesulfonate) propionate. Background technique: [0002] Ethyl 2-(4'-methylbenzenesulfonate) propionate is an important intermediate in the synthesis of phenoxycarboxylic acid herbicides such as quizalofop-p-p-p and oxaprop-p-p-p-p-p, which has unique optical and Biological activity has broad market prospects. Its molecular formula: C 12 h 16 o 5 S [0003] Structural formula: [0004] [0005] At present, the synthesis of ethyl 2-(4'-methylbenzenesulfonate)propionate basically adopts the traditional triethylamine process, which not only has the defects of slow reaction speed and low conversion rate, but also has the disadvantages of The recovery rate of triethylamine is low, and the shortcoming of environmental pollution is big. Invention content: [0006] The technica...

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Application Information

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IPC IPC(8): C07C309/73
Inventor 何普泉赵邦斌苏朝辉陈克付丁云好
Owner 陈克付
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