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Eye drops for cataract and its preparing method

A technology for eye drops and cataracts, applied in peptide/protein components, tripeptide components, sensory diseases, etc., can solve problems such as vision and lens opacity of patients who cannot prevent cataract progression, delay cataract formation, etc., to delay the formation of cataracts , Significant healing effect, absorption-increased effect

Inactive Publication Date: 2007-01-24
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Although the use of this eye drop can delay the formation of cataract, it cannot prevent the progression of cataract and improve the patient's vision and lens opacity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～7

[0017] Highly active baker's yeast is used as a yeast strain, cultivated in a shaking table at 180r / min, 29°C for 60h, liquid fermentation to produce yeast, extracted with hot water at 100°C to extract reduced glutathione, centrifuged to take supernatant, crystallized and dried to obtain Reduced glutathione.

[0018] Shrimp meat is washed, pulverized and homogenized, extracted with water at 60°C for 3 times, then centrifuged and filtered, and the supernatant is desalted, purified and separated by strong acidic cation exchange resin, concentrated and sterilized, and dried to obtain taurine.

[0019] According to the formula of Examples 1-7 in Table 2, taurine, sodium hyaluronate, vitamin C, sodium chloride, benzalkonium bromide and EDTA-Na 2 Dissolve in 80mL sterile purified water together, then add boric acid and borax, filter through a 0.45μm microporous membrane filter until clarified, then add sterile purified water to make the total volume reach 100mL, measure pH and osmot...

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PUM

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Abstract

The present invention relates to a kind of eye drops for cataract and its preparation process. It features the pH value of 6.0-8.0, and the osmotic pressure of 250-400 mOsm / Kg H2O, and consists of component A 100 ml and component B 1500-2400 mg, where the component A consists of taurine 600-1200 mg, sodium hyaluronate 100-500 mg, vitamin C 500-1500 mg, boric acid 500-1500 mg, borax 150-250 mg, sodium chloride 200-400 mg, EDTA disodium 100-150 mg, benzalkonium bromide 2-5 mg and water for injection for the rest in each 100 ml, and the component B is reducing glutathione. The eye drops are used in treating cataract in early stage and middle stage.

Description

technical field [0001] The invention relates to an eye drop, in particular to a cataract eye drop and a preparation method thereof. Background technique [0002] Cataract is the leading cause of blindness worldwide and is estimated to affect approximately 25% of the human population. In most African and Asian countries, at least half of the blind are caused by cataracts. Cataract is also the most important eye disease causing blindness in my country. In order to prevent and treat cataracts at present, people have invented various eye drops, which have played a certain role in the treatment of cataracts. For example, the glutathione eye drops produced by Guangzhou Pharmaceutical Co., Ltd. is currently a commonly used eye drop for the treatment of cataracts and corneal injuries. It is mainly prepared from glutathione and benzalkonium chloride. Although the use of this eye drop can delay the formation of cataract, it cannot prevent the progression of cataract and improve the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/22A61K38/06A61P27/12A61K31/14A61K31/185A61K31/375A61K31/195A61K31/726
Inventor 孙恢礼林丽云翁世兵吴园涛李君郑建禄
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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