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Process for removing toxic component from oleum fructus bruceae

A technology of javanica javanica oil and gallbladder, which is applied in the field of removing toxic components, and can solve problems such as production, sales, and use of javanica javanica oil emulsion, hindering, restricting the expansion of production and wide application of javanica javanica oil emulsion

Active Publication Date: 2007-02-07
GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the presence of a small amount of water-soluble toxic components in the production raw material-Brucea javanica petroleum ether extract, the production, sales and use of Brucea javanica oil emulsion have always been troubled and hindered by its toxicity, which has restricted Brucea javanica oil to a certain extent Expanded production and clinical application of dairy preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Take 1.2 kg of crude Brucea javanica oil, add 2.4 L of sodium hydroxide solution with a concentration of 0.1% (w / v, the same below), mix well, let stand for 24 hours, separate layers, and discard the alkaline water layer. The oil layer is washed with purified water until the pH value of the eluate is 6.0, the water layer is discarded, and after the oil layer is evaporated to remove moisture, filter to obtain 1.0L of javanica javanica oil fine product, according to the refined javanica javanica oil quality standard (standard issued by the Ministry of Public Health WS 3 -B-2739-97) under the acid value item stipulates that the acid value of javanica javanica oil is 1.1, while the above-mentioned quality standard stipulates that the acid value should not be greater than 6.

Embodiment 2

[0011] Get Brucea javanica oil crude product 1.2kg, add concentration and be 0.3% sodium hydroxide solution 2.4L, operation process is with embodiment 1, obtains Brucea javanica oil fine product 1.0L, detects acid value, is 0.9.

Embodiment 3

[0013] Get Brucea javanica oil crude product 1.2kg, add concentration and be 0.5% sodium hydroxide solution 2.4L, operating process is with embodiment 1, obtains Brucea javanica oil fine product 1.0L, detects acid value, is 0.3.

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Abstract

The invention discloses a toxin removing method of extracted oleum fructus bruceae from traditional Chinese medicine, which is characterized by the following: the solvent is selected from 10-50% alcohol solution or 0.1-0.5% alkaline solution, which is 10% alcohol solution or 0.5% alkaline solution at best; the bulk rate of oleum fructus bruceae and solvent is 1:1-3 for oil and alcohol solution as well as oil and alkaline solution.

Description

technical field [0001] The invention relates to a method for removing toxic components from the oil of javanica javanica extracted from traditional Chinese medicine. Background technique [0002] Brucea javanica oil emulsion is a pure traditional Chinese medicine anti-cancer preparation. It is currently on the market in two dosage forms: injection and oral liquid. The Affiliated Hospital of China Medical University, Bethune Medical University Affiliated Hospital, Shanghai Chest Hospital, Anhui Medical University Affiliated Hospital and other nearly 300 clinical hospitals observed. Researchers observed 16 diseases and more than 30,000 patients, focusing on lung cancer (including lung cancer metastasis, Bone metastasis, lymphatic metastasis) esophageal cancer, gastric cancer, colorectal cancer, bladder cancer, liver cancer, etc. have been widely used in clinical practice. A large number of clinical tests have found that most cancer patients have greatly improved clinical symp...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P35/00
Inventor 黄光亮龙仲涛许小春黄子健
Owner GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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