Total flavone extract of maniod eibish, its preparation and application

A technology of hollyhock flowers and total flavonoids is applied in the application field of preparing medicines for treating nephritis, can solve problems such as instability, no nephritis disease has been seen, and achieve the effect of reliable curative effect

Inactive Publication Date: 2007-07-11
周亚球 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of this technical solution are: one, because the hexahydroxyflavone myricetin, gossin and their glycosides are unstable in 30% ethanol, it is not appropriate to elute the total flavonoids with 30% ethanol; Which flavonoid components and content of

Method used

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  • Total flavone extract of maniod eibish, its preparation and application
  • Total flavone extract of maniod eibish, its preparation and application
  • Total flavone extract of maniod eibish, its preparation and application

Examples

Experimental program
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Effect test

Embodiment 1

[0067] Take 1 kg of hollyhock peanut medicinal powder, add 10 times the amount of 80% ethanol and heat and reflux for extraction for 2 hours, extract 3 times in total, combine the extracts, let cool, filter, recover ethanol under reduced pressure until there is no alcohol, and concentrate to 60 ° C for relative Extraction with a density of 1.13; add boiling water equivalent to 5 times the amount of the crude drug, stir in several times to dissolve, filter, add the filtrate to a non-polar D101 macroporous adsorption resin column, wash 6 column volumes with water, and rinse with 10% Ethanol for 2 column volumes, 70% ethanol to AlCl free 3 reaction, collecting 70% ethanol eluate, concentrating the eluate under reduced pressure at a temperature lower than 60°C, and vacuum-drying to obtain the crude product of total flavonoids extract from marshmallow flowers; Ester-ethanol (76.89:38.79 V / V) was extracted under reflux three times, each time for 2 hours, the solvent was recovered, a...

Embodiment 2

[0069] Take 1 kg of hollyhock peanut medicinal powder, add 8 times the amount of 70% ethanol and heat and reflux for extraction for 2 hours, extract 3 times in total, combine the extracts, let cool, filter, recover ethanol under reduced pressure until there is no alcohol, and concentrate to 60°C for relative Extraction with a density of 1.14; add boiling water equivalent to 4 times the amount of the crude drug, stir several times to dissolve, filter, add the filtrate to a weakly polar AB-8 macroporous adsorption resin column, wash 8 column volumes with water, and use 10% ethanol for 2 column volumes, 70% ethanol to AlCl free 3 reaction, collecting 70% ethanol eluate, concentrating the eluate under reduced pressure at a temperature lower than 60°C, and vacuum-drying to obtain the crude product of total flavonoids extract from marshmallow flowers; Ester-ethanol (76.89:38.79 V / V) was extracted under reflux three times, each time for 2 hours, the solvent was recovered, and the pro...

Embodiment 3

[0071] Take 1 kg of hollyhock peanut medicine powder, add 8 times the amount of 60% ethanol and heat and reflux for extraction for 2 hours, extract 3 times in total, combine the extracts, let cool, filter, recover the ethanol under reduced pressure until there is no alcohol, and concentrate to 60 ° C for relative Extraction with a density of 1.16; add boiling water equivalent to 4 times the amount of the crude drug, stir several times to dissolve, filter, add the filtrate to a medium-polarity DM301 macroporous adsorption resin column, wash 5 column volumes with water, and wash with 10% ethanol Elute 1 column volume with 70% ethanol to AlCl free 3 Reaction, collect 70% ethanol eluate, concentrate the eluate under reduced pressure at a temperature lower than 60°C, and dry in vacuum to obtain crude product of total flavonoids extract from marshmallow flowers; use 10 times the amount of ethyl acetate to obtain crude total flavonoids extract - Ethanol (76.89: 38.79 V / V) reflux extr...

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Abstract

The invention relates to a hollyhock sunflower chromocor extractive, wherein it is characterized in that: the chromocor content is 50-90%; the chromocor comprises 1. 0-5. 0% meletin-3-acacia glycoside, 8-24. 0% hyperin, 7. 0-20.0% isoquercitrin, 5. 0-15. 0% meletin-3-glucosidase, 3. 0-10.0% cotton-3-glucosidase, 0.5-5. 0% gale element, 0.5-5. 0% cotton, and 2. 0-8. 0% meletin, etc. The inventive extractive can be used to prepare the drug that treats nephritis, with high reliability.

Description

Technical field: [0001] The invention relates to an extract of total flavonoids from marshmallow flowers, a preparation method of the extract, a traditional Chinese medicine preparation, and an application thereof in preparation of medicines for treating nephritis. Background technique: [0002] Hollyhock flower is the dried flower of Abelmoschus Manihot (L.) Medic, a plant of the Malvaceae genus Okra. Developed into three types of new drugs - Huangkui Capsules for the treatment of nephritis. In the treatment of chronic glomerulonephritis, the total effective rate is 78.95% in the damp-heat syndrome group and 62.12% in the non-damp-heat syndrome group; the total effective rate in the treatment of chyluria is 84.62%; in the treatment of non-insulin-dependent diabetes complicated with diabetic nephropathy, the results show that the alcohol extract of marshmallow flower can Significantly reduce the proteinuria of DN in the clinical stage, combined with hypoglycemic and antihyp...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/16A61K9/20A61K9/48A61P13/12C07D311/30C07H1/08A61K133/00
Inventor 王先荣周亚球戴敏杜安全周正华
Owner 周亚球
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