Aromatic sulfone hydroxamic acids and their use as protease inhibitors

a technology of aromatic sulfone and hydroxamic acid, which is applied in the field of proteinase, can solve the problems of toxic side effects, toxicity, and reportedly observed toxic side effects, and achieve the effect of little or no inhibition
US20050101641A1Inactive Publication Date: 2005-05-12PHARMACIA CORP
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
PHARMACIA CORP
Publication Date
2005-05-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and / or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and / or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and / or aggrecanase activity.
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Description

PRIORITY CLAIM TO RELATED PATENT APPLICATION

[0001] This patent claims priority to U.S. Provisional Patent Application Ser. No. 60 / 290,375 (filed May 11, 2001). The entire text of U.S. Provisional Patent Application Ser. No. 60 / 290,375 is incorporated by reference into this patent.FIELD OF THE INVENTION

[0002] This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to aromatic sulfone hydroxarnates (also known as “aromatic sulfone hydroxamic acids”) that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and / or aggrecanase activity. This invention also is directed to compositions of such inhibitors, intermediates for the syntheses of such inhibitors, methods for making such inhibitors, and methods for preventing or treating conditions associated with MMP activity and / or aggrecanase activity, particularly pathological conditions. BACKGROUND OF THE INVENTION

[0003] Connectiv...

Claims

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