Methods for reducing viral load in HIV-1-infected patients

a technology for reducing viral load and hiv-1 infection, applied in the field of reducing viral load in hiv-1infected patients, can solve the problems of poor oral bioavailability, poor efficiency of the above-mentioned coreceptors, and local injection site irritation, so as to reduce the likelihood of a subject contracting hiv-1 infection, potentiate the effect of hiv-1 inhibitory activity, and reduce the likelihood of the subject contracting
US20070026441A1Inactive Publication Date: 2007-02-01PROGENICS PHARMA INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
PROGENICS PHARMA INC
Publication Date
2007-02-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

This method provides a method for reducing HIV-1 viral load in an HIV-1-infected human subject which comprises administering to the subject at a predefined interval effective HIV-1 viral load-reducing doses of (a) a humanized antibody designated PRO 140, or of (b) an anti-CCR5 receptor monoclonal antibody. This invention also provides a method for inhibiting in a human subject the onset or progression of an HIV-1-associated disorder, the inhibition of which is effected by inhibiting fusion of HIV-1 to CCR5+CD4+ target cells in the subject. This invention also provides a method for treating a subject infected with HIV-1 comprising administering to the subject (a) a monoclonal antibody which (i) binds to a CCR5 receptor on the surface of the subject's CD4+ cells and (ii) inhibits fusion of HIV-1 to the subject's CCR5+CD4+ cells, and (b) a non-antibody CCR5 receptor antagonist, in amounts effective to treat the subject.
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Description

[0001] This application claims benefit of U.S. Provisional Application No. 60 / 702,064, filed Jul. 22, 2005; U.S. Provisional Application No. 60 / 701,889, filed Jul. 23, 2005; U.S. Provisional Application No. 60 / 711,528, filed Aug. 26, 2005; and U.S. Provisional Application No. 60 / 715,619, filed Sep. 9, 2005; the contents of each of which in its entirety is hereby incorporated by reference into this application.

[0002] This invention was made with support under United States Government Grant Nos. A1046871 and A1066329 from the National Institute of Allergy and Infectious Diseases. Accordingly, the United States Government has certain rights in the subject invention.

[0003] Throughout this application, various publications are referenced in parentheses by author name and date, or by a patent or patent publication number. Full citations for these publications may be found at the end of the specification immediately preceding the claims. The disclosures of each of these publications in its...

Claims

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