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Methods and Compositions for Use in Treating Cancer
Inactive Publication Date: 2009-04-23
LITTLEFIELD BRUCE A +1
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Indeed, because it is not possible to determine the extent of metastasis, systemic approaches to therapy are usually undertaken when any evidence of spread is detected.
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[0014]The invention provides methods for treating cancer, involving administration of a halichondrin B analog, such as an analog having the following structure:
which is carried out in combination with a second approach to treatment.
[0015]There are numerous types of anti-cancer approaches that can be used in conjunction with halichondrin B analog treatment, according to the invention. These include, for example, treatment with chemotherapeutic agents (see below), biological agents (e.g., hormonal agents, cytokines (e.g., interleukins, interferons, granulocyte colony stimulating factor (G-CSF), macrophage colony stimulating factor (M-CSF), and granulocyte macrophage colony stimulating factor (GM-CSF)), chemokines, vaccine antigens, and antibodies), anti-angiogenic agents (e.g., angiostatin and endostatin), radiation, and surgery.
[0016]The methods of the invention can employ these approaches to treat the same types of cancers as those for which they are known in the art to be used, as ...
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Abstract
The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of, and claims priority from, U.S. patent application Ser. No. 10 / 687,526, filed Oct. 16, 2003, which is a continuation of U.S. patent application Ser. No. 10 / 272,167, filed Oct. 16, 2002 (now U.S. Pat. No. 6,653,341), which is a continuation-in-part of U.S. patent application Ser. No. 09 / 843,617, filed Apr. 26, 2001 (now U.S. Pat. No. 6,469,182), which is a continuation of U.S. patent application Ser. No. 09 / 677,485, filed Oct. 2, 2000 (now U.S. Pat. No. 6,365,759), which is a continuation of U.S. patent application Ser. No. 09 / 334,488, filed Jun. 16, 1999 (now U.S. Pat. No. 6,214,865), which claims benefit of U.S. Provisional Patent Application Ser. No. 60 / 089,682, filed Jun. 17, 1998 (now abandoned). The contents of the earlier filed applications are incorporated by reference herein in their entirety.FIELD OF THE INVENTION[0002]This invention relates to methods and compositions for use in treating can...
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Patent Type & Authority Applications(United States)
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