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Unit dosage of apadenoson

Inactive Publication Date: 2010-01-07
VIRGINIA UNIV OF +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]These and other aspects of the present invention have been accomplished in view of the discovery that no dose response curve is seen when 1 μg / kg or 2 μg / kg of Apadenoson is administered.

Problems solved by technology

There are inherent limitations and opportunities for operator error when parenterally administering a pharmaceutical agent on a weight basis.

Method used

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  • Unit dosage of apadenoson
  • Unit dosage of apadenoson
  • Unit dosage of apadenoson

Examples

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Embodiment Construction

[0010]The previously reported increase in coronary blood flow velocity (CBFV) corresponding to an increase in dose of Apadenoson from 0.5 to 2 μg / kg was based on the increase in CBFV in a limited number of patients (see FIG. 1). However, it has now been found that if one considers the entire sample of patients, as shown in FIG. 2, then at dose >1μg / kg and in particular between 1 and 2.5 μg / kg no dose response is seen. In light of this, Applicant has surprisingly discovered that instead of the weight-based dosing predicted by the results reported in FIG. 1, Apadenson can actually be administered via a unit dose.

[0011]Thus, in an embodiment, the present invention provides a novel unit dose of Apadenoson, comprising: (a) Apadenoson and (b) a pharmaceutically acceptable carrier, wherein the unit dose is suitable for parenteral administration.

[0012]In another embodiment, the unit dose is suitable for intravenous administration.

[0013]In another embodiment, the amount of Apadenoson present...

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Abstract

The present invention provides a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application claims the priority benefits of U.S. Provisional Applications No. 61 / 078,169, filed 3 Jul. 2008 and No. 61 / 155,937, filed 27 Feb. 2009, which are expressly incorporated fully herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging.BACKGROUND OF THE INVENTION[0003]Apadenoson, shown below, was first described as a pharmacologic stress agentthat can be used in clinical perfusion imaging techniques (e.g., for diagnosing and assessing the extent of coronary artery disease) in U.S. Pat. No. 6,322,771. This agent has since been taken into Phase I and II clinical trials. In 2005, Dr. Hendel et al reported to the American Heart Association on the preliminary results of 127 patient SPECT Tc99m sestamibi imaging studying comparing adenosine with Apadenoson using ei...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K31/7076A61P9/10
CPCA61K9/0019A61K31/519A61K47/40A61K47/02A61K47/12A61K31/7076A61P9/10A61K49/0004A61K9/08
Inventor HENDEL, ROBERTSTILLEY, WILLIAM B.WILLIAMS, SHANNON P.
Owner VIRGINIA UNIV OF