Radiolabeled lymphatic staining agents and methods for making

a technology of lymphatic staining agent and radiolabeled, which is applied in the field of radiolabeled lymphatic staining agent, can solve the problems of unanticipated consequences for both surgeons and patients alike, unfavorable treatment effect, and unusually painful radiocolloid injection, so as to avoid excessive radioactivity loss and more economical procedure

Inactive Publication Date: 2010-05-13
MALONEY THOMAS J +2
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0019]The method provides a more economical procedure for supplying radiolabeled lymphatic staining agent than current practice, in which the radioactive agent is made on site daily, or the entirety of the injectable staining agent is radiolabeled. In the preferred embodiment, the radioisotope selected has a half-life in the range of 2 days to 2 years, to avoid excessive loss of radioactivity during the shipment process.

Problems solved by technology

With the development of sentinel node biopsy came some unanticipated consequences for both surgeon and patient alike.
The injection of radiocolloid is unusually painful whether it is injected in small quantities intradermally or in larger quantities around the tumor.
Failure to allow clearance of the radiolabeled colloid “swamps” the gamma detector making identification of the sentinel node impossible or at least much more difficult.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example

[0038]Methylene Blue I-125

[0039]Radioiodination Procedure

[0040]1. Pre coat a 10 ml vial with 1.0 mg of Iodogen.

[0041]2. To the pre-coated Iodogen vial add 5.0 mg of Methylene Blue in 0.5 ml

[0042]3. Add a predetermined amount of NaI-125 (10-100 mCi) to a 12×75 mm plastic reaction tube.

[0043]4. Add 1.0 ml of Sodium Acetate (0.1M) and Acetic Acid (0.1M) pH=5.0 to the reaction tube.

[0044]5. Add 1.0 ml Sodium Iodate (4 mg / ml) to the plastic reaction tube.

[0045]6. Add 285 μg of Calcium Iodide to the plastic reaction tube.

[0046]7. Mix reaction tube and transfer contents into the sealed Iodogen vial that contains 5.0 mg of Methylene Blue.

[0047]8. Place Iodogen reaction vial on to a mixer / heat plate and heat and mix at 100° C. for 1.0 hour.

[0048]9. After incubation allow 10 minutes for vial cooling, and remove contents in a 10.0 ml syringe.

[0049]10. Add 1.0 ml of sodium acetate / acetic acid 0.1M

[0050]11. Using 10.0 ml syringe that contains the Methylene Blue withdraw the 1.0 ml of sodium acet...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
compositionaaaaaaaaaa
near-neutral salt solutionaaaaaaaaaa
affinityaaaaaaaaaa
Login to view more

Abstract

A radiolabeled lymphatic staining agent is mixed on site with a much larger amount, on a weight basis, of a non-radiolabeled lymphatic staining agent to form an injectable radiolabeled lymphatic staining agent suitable for surgical use in humans. Preferably, the radiolabel is I-125, because it has a 60-day half-life which enables it to be made off-site. The preferred radiolabeled lymphatic staining agent is iodinated methylene blue, because it can be mixed with a range of non-radioactive lymphatic staining agents, for example isosulfan blue, methylene blue, patent blue, and patent blue V, to provide the injected agent with sufficient radioactivity to enable machine detection. A method for making radioiodinated methylene blue is also disclosed.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application is a division of copending application Ser. No. 10 / 884,561, filed Jul. 2, 2004, now ______.SPECIFICATION[0002]1. Field of the Invention[0003]In one aspect, the invention relates to radiolabeled lymphatic staining agents which are useful for detection of the sentinel lymph node draining a tumor site. In another aspect, the invention relates to a method for making such a staining agent. In a further aspect, the invention relates to a method for providing radiolabeled staining agents for use in lymph node detection.[0004]2. Background of the Invention[0005]One of the major techniques for determining the prognosis of cancer, particularly breast cancer, involves examining the lymph nodes of the axilla or armpit of the patient. It is well known that a major aspect in assessing the stage of the cancer revolves around whether the cancer has spread to the lymph nodes. It is therefore important to have an effective technique for ide...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K51/04C07D279/18
CPCC07D279/18A61K51/0465
Inventor MALONEY, THOMAS J.CAMP, JR., ARTHUR E.HERNANDEZ, JESSE J.
Owner MALONEY THOMAS J
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap