Surface Modified Metal Nano-Particle and Use Thereof
a metal nanoparticle and surface modification technology, applied in the field of surface modification metal nanoparticles, can solve the problems of not being remarkable, and achieve the effect of convenient in vivo flow imaging
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example 1
Preparation of Surface-Modified Gold Nanoparticles
[0041]Gold chloride (III) trihydrate (HAuCl4.3H2O) was dissolved in de-ionized water to prepare a solution of 1.0×10−3 mol / L, and 20 mL of sodium citrate tribasic dehydrate solution in water (4×10−2 mol / L) was added to 200 mL of the above solution under refluxing, thereby reducing the surface of gold particles. After refluxing for 30 min, the temperature was reduced to 25° C., and the particle size was adjusted to approximately 20 nm. After completion of the reduction, the final particles were dialyzed in de-ionized water overnight using Spectra / Por®7 membrane (1,000 Da cut) to remove unreacted impurities.
[0042]The particles prepared without additional reaction after the reduction were designated as AuNP 1. 40 mL of 0.1 M thioglycolic acid (SH—CH2COOH), 40 mL of 0.1M 4-mercaptobenzoic acid (SH-Ph-COOH), 40 mL of 0.1 M 6-thioguanine (SH—C5H4N5), 40 mL of 0.1 M 2-mercaptoethanol (SH—CH2CH2OH), and 40 mL of 0.1 M 1-propanethiol (SH—CH2C...
example 2
Cluster Formation of Surface-Modified Gold Nanoparticles
[0048]AuNP 1, AuNP 2, AuNP 3, AuNP 4, AuNP 5, and AuNP 6 were dissolved in de-ionized water at a concentration of 2.4×1018 AuNPs / m3, respectively. Each of the solutions was dropped on a slide glass, and dried. Their images were obtained by scanning electron microscopy (SEM) (JEOL JSM-7401F SEM at an acceleration voltage of 15 kV) (3a) and zone-plate X-ray nanoscopy (3b), and shown in the upper part of FIGS. 3a and 3b. The number described in each picture corresponds to the particle number of FIG. 1. The average interparticle distance and average size of the clusters in 20 predetermined areas (200×200 nm2 and 3×3 mm2) are shown in the graph of the lower part of each figure.
example 3
Imaging of Sap Flow Using Surface-Modified Particles
[0049]It was tested whether the physical properties of the gold nanoparticles fabricated according to the present invention are controlled, and thus time-dependent flow motion of the clusters can be measured in the synchrotron X-ray. The gold nanoparticle used in the test was AuNP 5 suggested in FIG. 1. Starting from the concentration of 2.4×1018 AuNPs / m3, the concentration was increased 10 times to reach 2.4×1019 AuNPs / m3. Upon converting it into a weight of 20 nm gold nanoparticle, its concentration is 500 mg / kg H2O (500 ppm).
[0050]The flow motion of the clusters was measured using the synchrotron X-ray. The synchrotron X-ray source was obtained from 7B2 beamline at the Pohang Accelerator Laboratory (Pohang, Korea). Using a bending magnet, X-rays with a peak energy of 20.3 keV (8-30 keV range) were applied as a function of time without monochromator to obtain high energy. A CdWO4 crystal was used as a scintillator to convert the ...
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