Compositions and methods for treatment of filovirus-mediated diseases

a technology of filovirus and composition, applied in the field of composition and methods can solve the problems of no known antiviral therapy effective for treating filovirus-mediated diseases, filoviruses pose serious unmet health and bioterrorism concerns, and viruses are major health problems worldwide, so as to achieve less toxic, convenient treatment, and the effect of reducing the risk of infection
US20130289024A1Inactive Publication Date: 2013-10-31US ARMY MEDICAL RES MATERIEL COMMAND USAMRMC +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
US ARMY MEDICAL RES MATERIEL COMMAND USAMRMC
Publication Date
2013-10-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention features compositions, methods, and kits useful for the treatment of filovirus-mediated diseases, e.g., hemorrhagic fever caused by Ebola virus, in an animal.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of U.S. Ser. No. 12 / 710,203, filed Feb. 22, 2010, which claims benefit from U.S. Provisional Application No. 61 / 154,279, filed Feb. 20, 2009, which is hereby incorporated by reference.BACKGROUND OF THE INVENTION

[0002] The invention relates to the treatment of diseases caused by a filovirus.

[0003] Diseases caused by viruses are major health problems worldwide. Filoviruses are particularly deadly viruses that cause severe hemorrhagic fever in humans and non-human primates. Filoviruses are sporadically transmitted to humans from a natural reservoir species thought to be fruit bats, after which the virus can easily spread from the human having the infection to a caregiver through bodily fluids. Infection with a filovirus of the Ebola or Marburg genus causes death in 25% to 90% of human victims, often within 10 days from the first appearance of symptoms.

[0004] No known anti-viral therapies are effective for trea...

Claims

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