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6 results about "Hemorrhagic Fevers" patented technology

<p>Viral hemorrhagic fevers (VHFs) are a group of illnesses caused by four families of viruses. These include the <a href='https://medlineplus.gov/ebola.html'>Ebola</a> and Marburg, Lassa fever, and yellow fever viruses. VHFs have common features: they affect many organs, they damage the blood vessels, and they affect the body's ability to regulate itself. Some VHFs cause mild disease, but some, like Ebola or Marburg, cause severe disease and death.</p> <p>VHFs are found around the world. Specific diseases are usually limited to areas where the animals that carry them live. For example, Lassa fever is limited to rural areas of West Africa where rats and mice carry the virus.</p> <p>The risk for travelers is low, but you should avoid visiting areas where there are disease outbreaks. Because there are no effective treatments for some of these viral infections, there is concern about their use in <a href='https://medlineplus.gov/biodefenseandbioterrorism.html'>bioterrorism</a>.</p> <p >Centers for Disease Control and Prevention</p>

Construction method and application of mouse model with hemorrhagic fever with renal syndrome

The invention belongs to the technical field of construction methods of disease animal models, and particularly relates to a construction method and application of a renal syndrome hemorrhagic fever mouse model. According to the HTNV infected mouse model established by the method disclosed by the invention, the symptom of the experimental mouse is close to the clinical symptom of a severe hemorrhagic fever with renal syndrome after challenge, the complete lethality and repeatability are high, and the HTNV infected mouse model has the advantages of simple operation, low cost and high efficiency. The method can be used for research on the HTNV pathogenic mechanism and immune mechanism and research and development of antiviral drugs and vaccines, and has great application value for perfecting an HTNV full-chain prevention and control system.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

A vsv vector-based htnev vaccine and its preparation method and application

This invention relates to the field of vaccine preparation technology, specifically disclosing a VSV-based HTNV vaccine, its preparation method, and its application. The method involves constructing a recombinant plasmid by inserting the nucleotide sequence of the HTNV envelope glycoprotein into the recombinant VSV vector plasmid, followed by packaging and processing to obtain an immunogenic HTNV recombinant VSV vaccine. The HTNV vaccine prepared by this invention provides a novel candidate vaccine for the prevention and treatment of hemorrhagic fever with renal syndrome.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Crimean-Congo hemorrhagic fever virus M-segment nucleic acid vaccine and methods of use and production

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic fever disease in humans. Currently, no licensed CCHF vaccines exist, and the protective epitopes remain unclear. Here, we tested a DNA vaccine expressing the M-segment glycoprotein precursor gene (GPC) of the laboratory CCHFV strain CCHFV-IbAr 10200 (CCHFV-M10200). Increasing the dose of CCHFV-M 10200 provides complete protection from homologous CCHFV challenge in mice, and significant (80%) protection from challenge with the clinically relevant, heterologous CCHFV-Afg09-2990 strain. We also report complete protection from CCHFV-Afg09-2990 challenge following vaccination with a CCHFV-Afg09-2990 GPC expressing DNA vaccine (CCHFV-M Afgog). Finally, we show that the non-structural M-segment protein, GP38, influences CCHF vaccine immunogenicity and provides significant protection from homologous CCHFV challenge. Our results demonstrate that M-segment DNA vaccines elicit protective CCHF immunity and further illustrate the immunorelevance of GP38.
Owner:UNITED STATES OF AMERICA THE AS REPRESENTED BY THE SEC OF THE ARMY

Primers, kits and methods for detecting the causative agent of hemorrhagic fever with renal syndrome

The application discloses primers, a kit and a method for detecting pathogenic bacteria of fever with hemorrhage syndrome, and nucleotide sequences of the primers are shown as SEQ ID NO. 1 to SEQ ID NO. 262. In the application, 131 pairs of specific primers are designed according to highly-conserved regions of 26 pathogenic bacteria of fever with hemorrhage related diseases, and a 26-pathogenic-bacteria detection method for fever with hemorrhage is established. The detection method can more completely cover the detection of pathogenic bacteria of fever with hemorrhage related diseases, has high accuracy, strong specificity and high sensitivity, can realize rapid detection in a short TAT (time to answer) of 15 hours, reduces mortality, and improves precise medication.
Owner:CHANGSHA KINGMED MEDICAL DIAGNOSTICS INST

Crispr effector system based diagnostics for hemorrhagic fever detection

The embodiments disclosed herein utilize RNA targeting effectors to provide a robust CRISPR-based diagnostic for hemorrhagic fever virus applications. Embodiments disclosed herein can differentiate between hemorrhagic fever viruses that present with similar symptoms, as well as between strains of a hemorrhagic fever virus.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE +1

Targeted sequencing primer sets and kits for detecting a variety of pathogenic microorganisms in murine species

The application discloses a kind of target sequencing primer set and kit for detecting multiple rodent carrying pathogenic microorganisms.The nucleotide sequence of the primer set is shown as SEQ ID NO:1-400.The kit comprises the primer set shown as SEQ ID NO:1-400.The application can simultaneously detect 50 kinds of rodent carrying pathogenic microorganisms, with the advantages of high detection throughput, clear pathogen spectrum range, low sequencing cost, high sensitivity, and no influence of host nucleic acid, etc.The target sequencing primer set and kit are developed for common pathogen spectrum carried by rodents, which can effectively make up for the shortcomings of prior art, expand the detection range, improve the detection sensitivity, and provide key technical support for early warning, prevention and control of plague, hemorrhagic fever with renal syndrome, fever with thrombocytopenia syndrome and other rodent-borne diseases.
Owner:TECH CENT OF GUANGZHOU CUSTOMS