Methods for treating or predicting risk of a ventricular tachyarrhythmia event

Abstract

Provided herein are methods that include (i) determining a level of soluble ST2 in a biological sample from a subject, (i) comparing the level of soluble ST2 in the biological sample to a reference level of soluble ST2 (e.g., a level of soluble ST2 in the subject at an earlier time point), and (iii) selecting, implanting, replacing, or reprogramming an implanted cardiac device, e.g., an ICD, CRT, or CRT-D device, for a subject having an elevated level of soluble ST2 in the biological sample compared to the reference level of soluble ST2, or selecting a subject for participation in, or stratifying a subject participating in, a clinical study of a treatment for reducing the risk of a ventricular tachyarrhythmia (VTA) event. Also provided are methods for evaluating the risk of a VTA event in a subject. Also provided are kits for performing any of these methods.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims to the benefit of U.S. Provisional Patent Application No. 61 / 649,202, filed May 18, 2012. The contents of the foregoing are incorporated herein by reference in their entirety.TECHNICAL FIELD[0002]Provided herein are methods that include determining a level of soluble ST2 in a biological sample from a subject, comparing the level of soluble ST2 in the biological sample to a reference level of soluble ST2 (e.g., a level of soluble ST2 in the subject at an earlier time point), and selecting, implanting, replacing, or reprogramming an implanted cardiac device, e.g., an ICD, CRT, or CRT-D device, for a subject having an elevated level of soluble ST2 in the biological sample compared to the reference level of soluble ST2.[0003]Also provided are methods for selecting a subject for participation in, or stratifying a subject participating in, a clinical study of a treatment for reducing the risk of a ventricular tachyarrhyt...

AI Technical Summary

Benefits of technology

[0027]By the term “cardiac resynchronization therapy device” or “CRT device” is meant a small electrical biventricular pacing medical device with at least one lead (e.g., three leads to the right atrium, right vent

Problems solved by technology

When the heart beats excessively rapidly, the heart pumps less efficiently, and provides less blood flow to the rest of the body.

The increased heart rate also leads to increased work and oxygen demand by the heart, which can lead to rate-related ischemia.

Some patients diagnosed with heart failure and receiving s

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