Methods for treating or predicting risk of a ventricular tachyarrhythmia event

Abstract

Provided herein are methods that include (i) determining a level of soluble ST2 in a biological sample from a subject, (i) comparing the level of soluble ST2 in the biological sample to a reference level of soluble ST2 (e.g., a level of soluble ST2 in the subject at an earlier time point), and (iii) selecting, implanting, replacing, or reprogramming an implanted cardiac device, e.g., an ICD, CRT, or CRT-D device, for a subject having an elevated level of soluble ST2 in the biological sample compared to the reference level of soluble ST2, or selecting a subject for participation in, or stratifying a subject participating in, a clinical study of a treatment for reducing the risk of a ventricular tachyarrhythmia (VTA) event. Also provided are methods for evaluating the risk of a VTA event in a subject. Also provided are kits for performing any of these methods.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims to the benefit of U.S. Provisional Patent Application No. 61 / 649,202, filed May 18, 2012. The contents of the foregoing are incorporated herein by reference in their entirety.TECHNICAL FIELD[0002]Provided herein are methods that include determining a level of soluble ST2 in a biological sample from a subject, comparing the level of soluble ST2 in the biological sample to a reference level of soluble ST2 (e.g., a level of soluble ST2 in the subject at an earlier time point), and selecting, implanting, replacing, or reprogramming an implanted cardiac device, e.g., an ICD, CRT, or CRT-D device, for a subject having an elevated level of soluble ST2 in the biological sample compared to the reference level of soluble ST2.[0003]Also provided are methods for selecting a subject for participation in, or stratifying a subject participating in, a clinical study of a treatment for reducing the risk of a ventricular tachyarrhyt...

AI Technical Summary

Benefits of technology

The patent is about a small device that helps improve heart function in patients who are at risk of future heart events. It uses electrical pacing to synchronize the pumping of the heart, which can make it beat more regularly. This device can be implanted in patients who have a slow heart rhythm and can potentially improve their symptoms.

Problems solved by technology

When the heart beats excessively rapidly, the heart pumps less efficiently, and provides less blood flow to the rest of the body.

The increased heart rate also leads to increased work and oxygen demand by the heart, which can lead to rate-related ischemia.

Some patients diagnosed with heart failure and receiving standard pharmacological therapy develop worsening disease, whereby such pharmacological therapy is no longer sufficient, and device therapy (e.g., ICD, CRT, or CRT-D device) becomes necessary to preserve these patients' lives.

In some embodiments, the risk of a VTA event is the risk of a VTA event within one year.

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