Methods and kits for diagnosing the prognosis of cancer patients

a cancer patient and prognosis technology, applied in the field of cancer patient prognosis diagnosis methods, can solve the problems of warranted aggressive treatment, and achieve the effects of less aggressive treatment regimen, high capacity for reconstituting, and good prognosis
US20160222461A1Inactive Publication Date: 2016-08-04NEW YORK UNIV
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
NEW YORK UNIV
Publication Date
2016-08-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The prognosis of a cancer patient can be determined by analyzing the modulation of expression of specified genes in the tumor tissue. Genes uniquely up-regulated in adult stem cells that can reconstitute the tissue of the tumor are analyzed for up-regulation in the patient's tumor. Up-regulation of a plurality of such genes in the tumor is an indication of good prognosis. Genes uniquely up-regulated in fetal stem cells are analyzed for up-regulation in the patient's tumor. Up-regulation of a plurality of such genes in the tumor are an indication of a poor prognosis. Specific genes are disclosed, the modulation of which, in a patient's prostate cancer tumor, will serve as an indication of prognosis. Patients with a good prognosis are subjected to watchful waiting. Patients with a poor prognosis are aggressively treated. Kits are provided containing a set of affinity reagents that specifically detect expression of the various genes.
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Description

[0001] This invention was made with government support under Grant No. 1 US1 RR029893 awarded by National Center for Research Resources, National Institutes of Health, DHHS, Grant No. RO1 CA132641 from the National Cancer Institute, National Institutes of Health, DHHS, and Grant UL1 TR000038 from the National Center for Advancing Translational Sciences of the National Institutes of Health. The government has certain rights in the invention.FIELD OF THE INVENTION

[0002] The present invention relates generally to methods for diagnosing the prognosis of cancer patients, and more particularly to the analysis of uniquely up-regulated adult stem cell genes and uniquely up-regulated fetal stem cell genes in the tumor cells of the patient. The presence in the patient's tumor cells of a significant number of uniquely up-regulated adult stem cell genes (adult stem cells have a signature of quiescence), in stem cells having a high capacity to reconstitute the normal tissue from which the tumor or...

Claims

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