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Composition and method for the treatment of obesity

a technology for obesity and composition, applied in the field of composition and method for the treatment of obesity, can solve the problems of increased risk of heart attack and stroke in high-risk cardiac patients, potentially serious psychiatric disorders, etc., and achieve the effects of increasing the protective effect against dna, and reducing the risk of strok

Inactive Publication Date: 2016-10-13
PRASAD KODIMULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a composition made from Helianthus annuus seed that can help manage obesity. The composition contains a high level of polyphenols, specifically chlorogenic acid, which has been found to have various beneficial effects such as anti-oxidant activity, inhibiting pancreatic lipase, and protecting against oxidative DNA damage. The composition also exhibits an antioxidant scavenging activity of about 87.88% and a superoxide scavenging activity of about 80.41%. The composition has been found to be safe and non-toxic. Overall, this patent provides a technical solution for managing obesity using a natural composition containing chlorogenic acid.

Problems solved by technology

Obesity is defined in terms of body mass index (BMI), which is calculated as body weight divided by square of height, and it is mainly a result of an imbalance between energy intake and expenditure.
Sibutramine and rimonabant were recently withdrawn from the market due to adverse side effects.
For example, Sibutramine could lead to an increased risk of heart attack and stroke in high risk cardiac patients, whereas the latter could lead to potentially serious psychiatric disorders (Ghazali et al., 2013).

Method used

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  • Composition and method for the treatment of obesity
  • Composition and method for the treatment of obesity
  • Composition and method for the treatment of obesity

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Sunflower Material

[0066]100 kg of sunflower seed powder was taken into a cleaned vertical 1.0 KL extractor. The bottom of the extractor comprises of a perforated plate on which filtration cloth was fixed. The bottom of the extractor was connected to a transfer pump input and output of the transfer pump was connected to T bend. One end was connected to extractor top for circulation of extraction mass while extraction period and other end of T bend were connected to receiver tank.

[0067]The above mentioned mass was extracted with 7-8 bed volumes of demineralized water. Extraction was continued at 80-85° C. temperature about 7-8 hrs with continuous circulation of extract with transfer pump. After completion of extraction, filter the extract through 5 micron SS candle filter and collect clear extract in a receiver tank. The bed was re-extracted by adding 5-6 bed volumes of demineralized water 3 more times at 80-85° C. temperature about 7-8 hrs and filter through 5 micron S...

example 2

Spectrophotometric and HPLC Derivation

[0069]The material obtained under Example 1 was subjected to phyto-chemical derivation through spectrophotometric and HPLC estimations.

[0070]A. Derivation of Polyphenol Content by Folin-Ciocalteous Method

Standard Preparation:

[0071]Dissolve 100 mg of STD (99.9% pure) in 100 ml of volumetric flask by using 50% methanol solution (1000 ppm Chlorogenic acid stock standard). From this 1000 ppm stock standard prepare 30 ppm, 60 ppm, 90 ppm, 120 ppm, 150 ppm and 180 ppm standard solutions by diluting using 50% methanol solution.

Sample Preparation:

[0072]15-20 mg of the preparation from Example 1 was placed into 100 ml of volumetric flask, about 50 ml of 50% methanol solution was added and the mixture sonicated for 5 mins, then diluted to 100 ml with 50% methanol, then further diluted to 5.0 ml of above solution to 10 ml using 50% methanol.

[0073]Prepared a series of test tubes (one for blank, each STDs and samples) each containing 15 ml of 50% methanol so...

example 3

Toxicity Study

[0097]The Ames test is widely used in the determination of possible gene mutations by various agents. A positive response in any single bacterial strain either with or without metabolic activation is sufficient to designate a substance as an antimutagen. It is estimated that 90% of all carcinogens also are mutagens, and with this figure in mind, Bruce Ames and his colleagues developed a test in the 1970s that uses special bacteria that are very sensitive to mutagenic agents. The Food and Drug Administration (FDA) now uses the Ames test to screen many chemicals rapidly and inexpensively. Those few chemicals that appear to be mutagenic by the Ames test are tested further in animals to assess their ability to cause cancer.

[0098]The Salmonella mutagenicity test was specifically designed to detect chemically induced mutagenesis both in presence and absence of metabolic activation. This assay helps to identify substances that can produce genetic damage that leads to gene mut...

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Abstract

A composition formulated from sunflower, including Helianthus annulus and methods for use of the composition for treating obesity in a subject.

Description

FIELD OF THE INVENTION[0001]The invention generally relates to a composition formulated from sunflower and methods for the use of the composition in the treatment of obesity and obesity management.BACKGROUND[0002]Sunflowers are botanically classified as in the genus Helianthus belonging to family compositae. They are a large plant and are grown throughout the world because of their relatively short growing season. Domesticated sunflowers typically have a single stalk topped by a large flower. This is significantly different from the smaller, multiply branched wild sunflower. During the growing season, the individual flowers are each pollinated. The sunflower plants reach various heights, but most are from 1.52-2.1 meters tall. Seed development begins moving from the outer rim of the flower toward the center. It generally takes 30 days after the last flower is pollinated for the plant to mature (Agribusiness Handbook, 2010).[0003]Sunflowers, which are used mainly as an ornamental cro...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/216A61K36/28
CPCA61K36/28A61K31/216A61K31/7032A61K2300/00
Inventor PRASAD, KODIMULE
Owner PRASAD KODIMULE
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